Avosentan Reduces Albumin Excretion in Diabetics with Macroalbuminuria

Despite the first-line use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), there is still a large need to improve the prevention and progression of diabetic nephropathy and its associated cardiovascular events. Endothelin antagonists have shown anti-infl...

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Bibliographic Details
Published in:Journal of the American Society of Nephrology 2009-03, Vol.20 (3), p.655-664
Main Authors: Wenzel, Rene[Combining Acute Accent] R., Littke, Thomas, Kuranoff, Susan, Ju[Combining Diaeresis]rgens, Christiane, Bruck, Heike, Ritz, Eberhard, Philipp, Thomas, Mitchell, Anna
Format: Article
Language:English
Subjects:
Aged
Albuminuria - complications
Albuminuria - drug therapy
Albuminuria - urine
Angiotensin II Type 1 Receptor Blockers - therapeutic use
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Biological and medical sciences
Clinical Research
Diabetes. Impaired glucose tolerance
Diabetic Nephropathies - drug therapy
Diabetic Nephropathies - urine
Dose-Response Relationship, Drug
Double-Blind Method
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Endothelin A Receptor Antagonists
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Humans
Hypoglycemic Agents - therapeutic use
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Pyridines - administration & dosage
Pyridines - adverse effects
Pyridines - therapeutic use
Pyrimidines - administration & dosage
Pyrimidines - adverse effects
Pyrimidines - therapeutic use
Citations: Items that cite this one
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