Renal cell carcinoma co-existent with other renal disease: clinico-pathological features in pre-dialysis patients and those receiving dialysis or renal transplantation

• Published in: Nephrology, dialysis, transplantation dialysis, transplantation, 2004-11, Vol.19 (11), p.2789-2796
• Main Authors: Peces, Ramón, Martínez-Ara, Jorge, Miguel, José Luis, Arrieta, Javier, Costero, Olga, Górriz, José Luis, Picazo, Mari-Luz, Fresno, Manuel
• Format: Article
• Language: English
• Subjects: acquired cystic kidney disease; Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Carcinoma, Renal Cell - epidemiology; Carcinoma, Renal Cell - pathology; Comorbidity; Emergency and intensive care: renal failure. Dialysis management; Female; haemodialysis; Humans; Intensive care medicine; Kidney Diseases, Cystic - epidemiology; Kidney Neoplasms - epidemiology; Kidney Neoplasms - pathology; Kidney Transplantation; Male; Medical sciences; Middle Aged; nephrectomy; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; pre-dialysis; Prognosis; renal cell carcinoma; Renal Dialysis; Renal failure; renal transplantation; Risk Factors; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system; Time Factors
• ISSN: 0931-0509; 1460-2385; 1460-2385
• DOI: 10.1093/ndt/gfh458

Background. Patients on chronic dialysis are prone to developing acquired cystic kidney disease (ACKD), which may lead to the development of renal cell carcinoma (RCC). The risk factors for the development of RCC so far have not been determined in pre-dialysis patients with co-existent renal disease. The aim of this study was to evaluate the clinico-pathological features of RCC in pre-dialysis patients with associated renal diseases or in those undergoing chronic dialysis and renal transplantation. Methods. We studied 32 kidneys from 31 patients with RCC and associated renal diseases. Of those, 18 kidneys were from 17 patients not on renal replacement therapy (RRT) when diagnosed with RCC; 14 patients received dialysis or dialysis followed by renal transplantation. Several clinico-pathological features were analysed and compared between the two groups. Results. Overall, there was a preponderance of males (75%); nephrosclerosis was the predominant co-existent disease (31%). The median intervals from renal disease to RCC in the dialysis and transplanted groups were significantly longer than in the pre-dialysis group (15.8±1.1 vs 2.4±0.7 years, P