Formulation and evaluation of diclofenac sodium buccoadhesive discs

Twenty diclofenac sodium buccoadhesive discs containing Cp974p, polycarbophil, PEO, SCMC-medium viscosity (SCMC-MV), SCMC-ultrahigh viscosity (SCMC-UHV) or their combinations were prepared. These buccoadhesive discs were evaluated for release pattern, swelling capacity, surface pH, mucoadhesion perf...

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Bibliographic Details
Published in:International journal of pharmaceutics 2004-11, Vol.286 (1), p.27-39
Main Authors: El-Samaligy, M.S., Yahia, S.A., Basalious, E.B.
Format: Article
Language:English
Subjects:
Acrylates - administration & dosage
Acrylates - chemistry
Acrylates - pharmacokinetics
Acrylic Resins - administration & dosage
Acrylic Resins - chemistry
Acrylic Resins - pharmacokinetics
Administration, Buccal
Animals
Biological and medical sciences
Biological Availability
Buccoadhesive disc
Carboxymethylcellulose Sodium - chemistry
Carboxymethylcellulose Sodium - classification
Chickens
Diclofenac - administration & dosage
Diclofenac - metabolism
Diclofenac - pharmacokinetics
Diclofenac sodium
Dogs
Drug Carriers - chemistry
Drug Carriers - classification
Drug Carriers - pharmacokinetics
Drug Combinations
Drug Evaluation, Preclinical - methods
Egypt
General pharmacology
Medical sciences
Mouth Mucosa - drug effects
Mouth Mucosa - pathology
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyethylene Glycols - administration & dosage
Polyethylene Glycols - chemistry
Polyethylene Glycols - pharmacokinetics
Relative bioavailability
Tablets, Enteric-Coated - administration & dosage
Tablets, Enteric-Coated - chemistry
Tablets, Enteric-Coated - pharmacokinetics
Technology, Pharmaceutical - methods
Time Factors
Viscosity
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Summary:Twenty diclofenac sodium buccoadhesive discs containing Cp974p, polycarbophil, PEO, SCMC-medium viscosity (SCMC-MV), SCMC-ultrahigh viscosity (SCMC-UHV) or their combinations were prepared. These buccoadhesive discs were evaluated for release pattern, swelling capacity, surface pH, mucoadhesion performance, and in vitro permeation of diclofenac sodium through buccal membranes. In vivo testing of mucoadhesion time, strength of adhesion, irritation, bitterness due to drug swallowing and disc disintegration in the buccal cavity were also performed. Drug bioavailability of a selected diclofenac sodium buccoadhesive product was then compared with that of Voltarin ® 100 SR tablet. The percentage relative bioavailability of diclofenac sodium from the selected buccoadhesive disc 50 mg was found to be 141.31%.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2004.07.033