Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese women

• Published in: Clinical endocrinology (Oxford) 2009-04, Vol.70 (4), p.569-574
• Main Authors: Choi, K. M., Kim, T. N., Yoo, H. J., Lee, K. W., Cho, G. J., Hwang, T. G., Baik, S. H., Choi, D. S., Kim, S. M.
• Format: Article
• Language: English
• Subjects: Acute-Phase Proteins; Adult; Biological and medical sciences; Blood Glucose - metabolism; Body Mass Index; C-Reactive Protein - metabolism; Case-Control Studies; Cholesterol - blood; Endocrinopathies; Exercise - physiology; Fatty Acid-Binding Proteins - blood; Female; Fundamental and applied biological sciences. Psychology; Humans; Korea; Lipocalin-2; Lipocalins - blood; Medical sciences; Metabolic diseases; Middle Aged; Obesity; Obesity - blood; Obesity - ethnology; Obesity - physiopathology; Proto-Oncogene Proteins - blood; Resistance Training; RNA Polymerase II - blood; Vertebrates: endocrinology
• ISSN: 0300-0664; 1365-2265
• DOI: 10.1111/j.1365-2265.2008.03374.x

Summary Objective  Lipocalin family proteins, including adipocyte fatty acid‐binding protein (A‐FABP), lipocalin‐2 and retinol‐binding protein 4 (RBP4), have recently been identified as novel adipokines associated with obesity, type 2 diabetes and the metabolic syndrome. We have evaluated the effect of exercise training on lipocalin family proteins and inflammatory markers. Study subjects  Thirty obese Korean women and 15 age‐matched nonobese control subjects were studied. Design  Concentrations of the lipocalin family proteins were compared between obese and nonobese women and were evaluated before and 3 months after an exercise programme consisting of aerobic exercise (45 min/session, 300 kcal/day) and muscle strength training (20 min/session, 100 kcal/day) five times a week. Results  Obese women exhibited higher A‐FABP levels compared to nonobese women (21·4 ± 6·4 µg/l vs. 13·6 ± 4·4 µg/l, P