Synthesis and Cytotoxicity Screening of Piperazine-1-carbodithioate Derivatives of 2-Substituted Quinazolin-4(3H)-ones

A new series of piperazine‐1‐carbodithioate derivatives of 2‐substituted quinazolin‐4(3H)‐ones were synthesized via a five‐steps procedure starting from 2‐amino‐5‐methylbenzoic acid. The cytotoxicity of the resulting compounds against A‐549 (human lung cancer), HCT‐8 (human colon cancer), HepG2 (hum...

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Bibliographic Details
Published in:Archiv der Pharmazie (Weinheim) 2009-03, Vol.342 (3), p.182-189
Main Authors: Cao, Sheng-Li, Guo, Yan-Wen, Wang, Xian-Bo, Zhang, Mei, Feng, Yu-Ping, Jiang, Yu-Yang, Wang, Yue, Gao, Qian, Ren, Jian
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Cell Line, Tumor
Cell Survival - drug effects
Cytotoxicity
Dithiocarbamate
Drug Screening Assays, Antitumor
Humans
Quinazolin-4(3H)-one
Quinazolinones - chemical synthesis
Quinazolinones - pharmacology
Screening
Synthesis
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Summary:A new series of piperazine‐1‐carbodithioate derivatives of 2‐substituted quinazolin‐4(3H)‐ones were synthesized via a five‐steps procedure starting from 2‐amino‐5‐methylbenzoic acid. The cytotoxicity of the resulting compounds against A‐549 (human lung cancer), HCT‐8 (human colon cancer), HepG2 (human liver cancer), and K562 (human myelogenous leukaemia) cell lines was determined by the MTT assay. Preliminary screening results of these compounds are reported.
ISSN:0365-6233
1521-4184
DOI:10.1002/ardp.200800148