Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth

ABSTRACT Removal of apoptotic cells by neighboring viable cells or professional phagocytes is essential for the maintenance of tissue homeostastis. Here we show that the phagocytosis of apoptotic Jurkat T cells by mouse epithelial cells (HC‐11) and peritoneal macrophages leads to the secretion of gr...

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Bibliographic Details
Published in:The FASEB journal 2004-11, Vol.18 (14), p.1716-1718
Main Authors: Golpon, Heiko A., Fadok, Valerie A., Taraseviciene-Stewart, Laima, Scerbavicius, Robertas, Sauer, Clemens, Welte, Tobias, Henson, Peter M., Voelkel, Norbert F.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cell Line
Cell Proliferation
Cell Survival
endothelial cells
Endothelium, Vascular - cytology
Endothelium, Vascular - drug effects
epithelial cells
Growth Substances - metabolism
Growth Substances - pharmacology
Humans
Jurkat Cells
Mice
Microcirculation - cytology
Phagocytes - metabolism
Phagocytosis
Vascular Endothelial Growth Factor A - metabolism
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Summary:ABSTRACT Removal of apoptotic cells by neighboring viable cells or professional phagocytes is essential for the maintenance of tissue homeostastis. Here we show that the phagocytosis of apoptotic Jurkat T cells by mouse epithelial cells (HC‐11) and peritoneal macrophages leads to the secretion of growth and survival factors. We characterized VEGF as one of these factors which subsequently promote the proliferation of endothelial cells. Further we demonstrate that the phagocytosis of apoptotic bodies inhibits both spontanous and UV‐irradiation‐induced apoptosis in endothelial and epithelial cells. These effects were not observed when phagocytes had been exposed to viable or necrotic Jurkat T cells. We conclude that phagocytosis of apoptotic cells leads to secretion of growth and survival factors by phagocytes that represents a new form of life‐promoting cell‐cell interaction.
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.04-1853fje