Postural tremor in Wilson's disease: A magnetoencephalographic study

The following study included 5 Wilson's disease (WD) patients showing a right‐sided postural forearm tremor (4–6 Hz) and addressed the question of whether the primary motor cortex (M1) is involved in tremor generation. Using a 122‐channel whole‐head neuromagnetometer and surface electromyogram...

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Bibliographic Details
Published in:Movement disorders 2004-12, Vol.19 (12), p.1476-1482
Main Authors: Südmeyer, Martin, Pollok, Bettina, Hefter, Harald, Gross, Joachim, Wojtecki, Lars, Butz, Markus, Timmermann, Lars, Schnitzler, Alfons
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain - pathology
Brain - physiopathology
coherence
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
DICS
Electromyography
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hepatolenticular Degeneration - complications
Hepatolenticular Degeneration - pathology
Hepatolenticular Degeneration - physiopathology
Humans
Magnetic Resonance Imaging
Magnetoencephalography - methods
Male
Medical sciences
MEG
Middle Aged
MRI
Nervous system (semeiology, syndromes)
Neurology
Posture - physiology
Severity of Illness Index
tremor
Tremor - diagnosis
Tremor - etiology
Tremor - physiopathology
Wilson's disease
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Summary:The following study included 5 Wilson's disease (WD) patients showing a right‐sided postural forearm tremor (4–6 Hz) and addressed the question of whether the primary motor cortex (M1) is involved in tremor generation. Using a 122‐channel whole‐head neuromagnetometer and surface electromyogram (EMG), we investigated cerebromuscular coupling. Postural tremor was observed in a sustained 45‐degree posture of the right‐sided forearm. Data were analyzed using dynamic imaging of coherent sources (DICS), revealing cerebromuscular coupling between EMG and cerebral activity. Coherent sources were superimposed on individual high‐resolution T1‐weighted magnetic resonance images (MRI). Phase lags between EMG and cerebral areas showing strongest coherence were determined by means of a Hilbert transform of both signals. In all patients, postural tremor was associated with strong coherence between tremor EMG and activity in contralateral primary sensorimotor cortex (S1/M1) at tremor or double tremor frequency. Phase lag values between S1/M1 activity and EMG revealed efferent and afferent components in the corticomuscular coupling. Taken together, our results indicate that postural tremor in WD is mediated through a pathological oscillatory drive from the primary motor cortex. © 2004 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.20240