Antibody responses to intradermal recombinant hepatitis B immunization among HIV-positive subjects

We conducted a randomized, controlled clinical trial to determine the immunogenicity of intradermal immunization with recombinant hepatitis B vaccine among HIV-positive subjects. Induction of antibody concentration over 10 IU/L or four-fold increase in the antibody concentration against hepatitis B...

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Bibliographic Details
Published in:Vaccine 2004-11, Vol.23 (2), p.205-209
Main Authors: Ristola, Matti A., Vuola, Jenni M., Valle, Martti, von Reyn, C. Fordham
Format: Article
Language:English
Subjects:
Adult
Antiretroviral drugs
Applied microbiology
Biological and medical sciences
Drug therapy
Fundamental and applied biological sciences. Psychology
Hepatitis
Hepatitis B
Hepatitis B - prevention & control
Hepatitis B Antibodies - biosynthesis
Hepatitis B Vaccines - immunology
HIV
HIV Seropositivity - immunology
Human immunodeficiency virus
Human viral diseases
Humans
Immunization
Immunogenicity
Infectious diseases
Injections, Intradermal
Intradermal immunization
Male
Medical sciences
Microbiology
Miscellaneous
Public health
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Synthetic - administration & dosage
Vaccines, Synthetic - therapeutic use
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral hepatitis
Viral Hepatitis Vaccines - administration & dosage
Viral Hepatitis Vaccines - immunology
Virology
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Description
Summary:We conducted a randomized, controlled clinical trial to determine the immunogenicity of intradermal immunization with recombinant hepatitis B vaccine among HIV-positive subjects. Induction of antibody concentration over 10 IU/L or four-fold increase in the antibody concentration against hepatitis B surface antigen was regarded a successful immunization. Intradermal immunization induced protective immunity in 39% of participants who received three doses of recombinant hepatitis B vaccine. Intradermal immunization may provide a way to improve the outcome of hepatitis B vaccination among HIV-infected persons. Three doses of intradermal immunization alone induces protective immunity against hepatitis B as often as intramuscular immunization.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2004.05.010