Cognitive Dysfunction in Parkinson’s Disease: The Role of Frontostriatal Circuitry

It has been known for many years that the classic motor symptoms of Parkinson’s disease are accompanied by deficits of executive function that resemble those seen after frontal lobe damage in humans. What is less clear is how different components of frontostriatal circuitry contribute to these impai...

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Bibliographic Details
Published in:The Neuroscientist (Baltimore, Md.) Md.), 2004-12, Vol.10 (6), p.525-537
Main Author: Owen, Adrian M.
Format: Article
Language:English
Subjects:
Animals
Cognition - physiology
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Cognition Disorders - psychology
Corpus Striatum - pathology
Corpus Striatum - physiopathology
Dopamine - metabolism
Frontal Lobe - pathology
Frontal Lobe - physiopathology
Humans
Magnetic Resonance Imaging
Memory Disorders - etiology
Memory Disorders - physiopathology
Memory Disorders - psychology
Neural Pathways - pathology
Neural Pathways - physiopathology
Neuropsychological Tests
Parkinson Disease - complications
Parkinson Disease - physiopathology
Parkinson Disease - psychology
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Summary:It has been known for many years that the classic motor symptoms of Parkinson’s disease are accompanied by deficits of executive function that resemble those seen after frontal lobe damage in humans. What is less clear is how different components of frontostriatal circuitry contribute to these impairments. Recently, improved methods of clinical assessment and classification, combined with novel technical approaches, such as functional neuroimaging, have led to great advances in our understanding of the fundamental mechanisms that drive frontostriatal circuitry. As a direct result, it has been possible to redefine impairments of executive function in Parkinson’s disease more precisely in terms of the specific neuropsychological, neuroanatomical, and psychopharmacological mechanisms involved.
ISSN:1073-8584
1089-4098
DOI:10.1177/1073858404266776