Asymmetric Synthesis of Deoxypolypropionate Units via Stereoselective Hydrogenation of Optically Active Cycloheptatriene

Optically active polypropionate units were synthesized in 9−11 steps from 3,5-dimethylphenol. The sequence consists of the Büchner reaction controlled by a chiral 2,4-pentanediol tether and diastereoselective hydrogenation over Raney nickel.

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Bibliographic Details
Published in:Organic letters 2004-11, Vol.6 (24), p.4439-4442
Main Authors: Sugimura, Takashi, Sato, Yasuhiro, Im, Chun Young, Okuyama, Tadashi
Format: Article
Language:English
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Summary:Optically active polypropionate units were synthesized in 9−11 steps from 3,5-dimethylphenol. The sequence consists of the Büchner reaction controlled by a chiral 2,4-pentanediol tether and diastereoselective hydrogenation over Raney nickel.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0483596