Release of neurobiochemical markers of brain damage is related to the neurovascular status on admission and the site of arterial occlusion in acute ischemic stroke

The study aimed at an analysis of the kinetics of protein S100B and neuron-specific enolase (NSE) and their relation to the site of arterial occlusion in patients with acute ischemic stroke. We investigated 32 consecutive patients admitted within 6 h after stroke onset. Serial venous blood samples w...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the neurological sciences 2004-12, Vol.227 (1), p.49-53
Main Authors: Wunderlich, Michael T., Wallesch, Claus-W., Goertler, Michael
Format: Article
Language:English
Subjects:
Adult
Aged
Area Under Curve
Biological and medical sciences
Biomarkers - blood
Blood. Blood coagulation. Reticuloendothelial system
Brain Chemistry
Brain Injuries - blood
Brain Injuries - etiology
Cerebral Arterial Diseases - complications
Demography
Female
Humans
Linear Models
Male
Medical sciences
Middle Aged
Nerve Growth Factors - blood
Neurology
NSE
Outcome
Pharmacology. Drug treatments
Phosphopyruvate Hydratase - blood
Protein S100B
S100 Calcium Binding Protein beta Subunit
S100 Proteins - blood
Sonography
Statistics, Nonparametric
Stroke
Stroke - blood
Stroke - classification
Stroke - complications
Time Factors
Vascular diseases and vascular malformations of the nervous system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The study aimed at an analysis of the kinetics of protein S100B and neuron-specific enolase (NSE) and their relation to the site of arterial occlusion in patients with acute ischemic stroke. We investigated 32 consecutive patients admitted within 6 h after stroke onset. Serial venous blood samples were taken hourly between 1 and 6 h, and at 12, 18, 24, 48, 72, 96, and 120 h after stroke onset. The neurovascular status was assessed on admission and monitored by repetitive extracranial and transcranial duplex sonography. In all patients, infarct volume was calculated. The neurological deficit was quantified by the National Institutes of Health stroke scale score, and functional outcome after 3 months was assessed with the modified Rankin Scale. Patients with normal flow velocities in basal cerebral arteries at admission showed significantly less S100B release than those with main stem or multiple branch occlusions ( p
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2004.08.005