Anti-CD25 Antibodies Decrease the Ability of Human Dendritic Cells to Prime Allogeneic CD4 T Cells

Abstract Anti-CD25 monoclonal antibodies are largely used in clinical transplantation to prevent acute allograft rejection episodes. Although their effects on T lymphocytes have been extensively studied, their impact on human dendritic cells (DCs) has been less reported. Furthermore, the role of the...

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Bibliographic Details
Published in:Transplantation proceedings 2009-03, Vol.41 (2), p.695-697
Main Authors: Mnasria, K, Lagaraine, C, Velge-Roussel, F, Lebranchu, Y, Baron, C
Format: Article
Language:English
Subjects:
Acute Disease
Antibodies, Anti-Idiotypic - immunology
Antigens, CD - immunology
B7-1 Antigen - immunology
B7-2 Antigen - immunology
Biological and medical sciences
CD4 Antigens - immunology
CD4-Positive T-Lymphocytes - immunology
CD40 Antigens - immunology
CD40 Ligand - immunology
CD83 Antigen
Dendritic Cells - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft Rejection - immunology
Graft Rejection - prevention & control
HLA-DR Antigens - immunology
Humans
Immunoglobulins - immunology
Interleukin-2 Receptor alpha Subunit - immunology
Lymphocyte Activation
Medical sciences
Membrane Glycoproteins - immunology
Monocytes - immunology
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue, organ and graft immunology
Transplantation, Homologous - immunology
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Summary:Abstract Anti-CD25 monoclonal antibodies are largely used in clinical transplantation to prevent acute allograft rejection episodes. Although their effects on T lymphocytes have been extensively studied, their impact on human dendritic cells (DCs) has been less reported. Furthermore, the role of the interleukin-2 in DC functions has not yet been fully elucidated. In this study, we observed that stimulation of human monocyte-derived DCs with lipopolysa ccharide or CD40L strongly induced the expression of CD25. We showed that pretreatment of DC with anti-CD25 diminished their ability to prime T-helper cells. In contrast, humanized anti-CD25 monoclonal antibodies did not affect the up-regulation of CD86, CD80, CD83, HLA-DR, or CD40 induced by lipopolysaccharide stimulation. This study supported previously unrecognized effects of anti-CD25 monoclonal antibodies on DCs that may contribute to their clinical efficacy.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2009.01.028