A randomized comparison of the effects of aspirin and clopidogrel on thrombotic risk factors and C‐reactive protein following myocardial infarction: the CADET trial

• Published in: Journal of thrombosis and haemostasis 2004-11, Vol.2 (11), p.1934-1940
• Main Authors: Woodward, M., Lowe, G. D. O., Francis, L. M. A., Rumley, A., Cobbe, S. M.
• Format: Article
• Language: English
• Subjects: Aged; Aspirin - administration & dosage; Aspirin - pharmacology; Biomarkers - blood; Blood Coagulation Factors - analysis; Blood Coagulation Factors - drug effects; Blood Viscosity - drug effects; C-Reactive Protein - analysis; C-Reactive Protein - drug effects; coagulation; coronary heart disease; Double-Blind Method; Female; Humans; inflammation; Male; Middle Aged; Myocardial Infarction - complications; Myocardial Infarction - drug therapy; Platelet Aggregation Inhibitors - administration & dosage; Platelet Aggregation Inhibitors - pharmacology; platelets; Risk Factors; Thrombosis - drug therapy; Thrombosis - etiology; Thrombosis - prevention & control; Ticlopidine - administration & dosage; Ticlopidine - analogs & derivatives; Ticlopidine - pharmacology
• ISSN: 1538-7933; 1538-7836; 1538-7836
• DOI: 10.1111/j.1538-7836.2004.01017.x

A randomized, double‐blind multicenter trial—the Clopidogrel and Aspirin: Determination of the Effects on Thrombogenicity (CADET) trial—was carried out to compare the effects of clopidogrel vs. aspirin on thrombotic variables and C‐reactive protein (CRP), over a 6‐month period of treatment, in patients with an acute myocardial infarction within the previous 3–7 days, who were not scheduled for major surgery including coronary artery bypass grafting. Patients (n = 184) were randomly allocated to aspirin (75 mg day−1) or clopidogrel (75 mg day−1). Blood samples were taken at baseline and then at clinic visits at 1, 3 and 6 months. By 1 month, clottable and immunonephelometric fibrinogen, D‐dimer, von Willebrand factor, factor VIII and CRP were significantly (P  0.05) for any of the variables, whether or not potential confounding variables were adjusted for. Similarly, there were no differences between treatments in the difference between baseline and final values for any of the variables. Aspirin and clopidogrel were thus found to have similar effects on thrombotic variables and CRP in this patient population.