Lymphovascular invasion predicts poor outcome of urothelial carcinoma of renal pelvis after nephroureterectomy

• Published in: BJU international 2009-04, Vol.103 (8), p.1047-1051
• Main Authors: Chung, Shiu‐Dong, Wang, Shuo‐Meng, Lai, Ming‐Kuen, Huang, Chao‐Yuan, Liao, Chun‐Hou, Huang, Kuo‐How, Pu, Yeong‐Shiau, Chueh, Shih‐Chieh, Yu, Hong‐Jeng
• Format: Article
• Language: English
• Subjects: Adrenal Gland Neoplasms - mortality; Adrenal Gland Neoplasms - pathology; Adrenal Gland Neoplasms - surgery; Adrenalectomy - mortality; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Epidemiologic Methods; Female; Humans; kidney; Kidney Neoplasms - mortality; Kidney Neoplasms - pathology; Kidney Neoplasms - surgery; Kidneys; Lymphatic Metastasis; lymphvascular invasion; Male; Medical sciences; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Nephrectomy - methods; Nephrectomy - mortality; Nephrology. Urinary tract diseases; nephroureterectomy; Prognosis; Tumors of the urinary system; urothelial carcinoma
• ISSN: 1464-4096; 1464-410X
• DOI: 10.1111/j.1464-410X.2008.08253.x

OBJECTIVE To evaluate the significance of lymphovascular invasion (LVI) to predict cancer‐specific survival (CSS) in patients with renal pelvic urothelial carcinoma (UC). PATIENTS AND METHODS In all, 76 patients with primary renal pelvic UC were treated by nephroureterectomy (NU). Inclusion criteria included nonmetastatic renal pelvic UC with no previous history of bladder cancer, concomitant ureteric lesion, or neoadjuvant chemotherapy. Age, gender, adrenalectomized or not, pathological T stage, grade, and LVI were examined by univariate and multivariate analyses to determine which were independent risk factors. RESULTS In all, 38 men and 38 women were included with a mean (range) age of 66 (41–93) years. The median (range) follow‐up was 48  (15–88) months. At follow‐up, eight cancer‐related deaths (10.5%) were censored, and 66 patients (85.9%) were alive and disease‐free. LVI was the only significant predictor of CSS in the univariate and multivariate analyses. CONCLUSIONS Adrenal metastases from primary renal pelvic UCs were rare. The present results suggest that ipsilateral adrenalectomy is not necessary during radical NU for treating patients with renal pelvic UCs. LVI appears to be a better prognostic factor for predicting poor outcome of renal pelvic UC than pT stage or tumour grade when using the current tumour‐nodes‐metastases staging system.