Postprandial glucose monitoring in type 1 diabetes mellitus: use of a continuous subcutaneous monitoring device

• Published in: Diabetes/metabolism research and reviews 2004-11, Vol.20 (S2), p.S24-S31
• Main Authors: Manuel-y-Keenoy, Begoña, Vertommen, Jan, Abrams, Pascale, Van Gaal, Luc, De Leeuw, Ivo, Messeri, Dimitri, Poscia, Alessandro
• Format: Article
• Language: English
• Subjects: Adult; Aged; Blood Glucose - metabolism; Blood Pressure; Body Mass Index; continuous glucose monitoring; Diabetes Mellitus, Type 1 - blood; Fasting; Glycated Hemoglobin A - analysis; Humans; Insulin - therapeutic use; Lipids - blood; Middle Aged; Monitoring, Ambulatory - instrumentation; Monitoring, Ambulatory - methods; postprandial; Postprandial Period; Regression Analysis; type 1 diabetes mellitus
• ISSN: 1520-7552; 1520-7560
• DOI: 10.1002/dmrr.516

Background Pre‐prandial glucose gives insufficient information on glycemic excursions throughout the day. We aimed to test a continuous subcutaneous glucose‐monitoring device (GlucoDay®) to describe postprandial glucose changes. Methods In 23 T1DM patients, 24‐h GlucoDay® registrations were started about 14 h before receiving a standard breakfast B and 3 h later lunch L. Results The 3‐min glucose values were computed into parameters describing the postprandial changes after B and L. Two‐hour glucose was higher after B (243 ± 69 vs 180 ± 79 mg/dL after L, p < 0.0001). Maximum glycemia (313 ± 105 mg/dL after B and 304 ± 119 after L, p < 0.0001) was higher and was reached after 78 and 57 min respectively. Three‐hour AUC was higher but 30‐min AUC was lower after B (5725 ± 2414 vs 7488 ± 2208 min mg/dL after L, p = 0.004). Glucose spikes (maximum peak minus fasting plasma glucose) were similar after B and L but the difference between maximum and minimum values was smaller after B (165 ± 110 vs 219 ± 115 mg/dL after L, p = 0.020). Duration of hyperglycemic periods >200, 140 or 126 mg/dL were not different after B or L, but time spent at glucose