Endothelial dysfunction and inflammation after percutaneous coronary intervention

We studied 30 consecutive patients who underwent coronary stenting with respect to postprocedure endothelial dysfunction and levels of pre- and postprocedure cytokines. Patients with severe impairment of flow-mediated dependent dilation, but not flow- mediated independent dilation, had higher concen...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2004-12, Vol.94 (11), p.1420-1423
Main Authors: Blum, Arnon, Schneider, David J., Sobel, Burton E., Dauerman, Harold L.
Format: Article
Language:English
Subjects:
Aged
Angioplasty, Balloon, Coronary - adverse effects
Biological and medical sciences
C-Reactive Protein - analysis
Cardiology. Vascular system
Coronary Artery Disease - therapy
Coronary vessels
Cytokines
Diseases of the cardiovascular system
Endothelium - physiology
Female
Humans
Inflammation - etiology
Male
Medical sciences
Middle Aged
Predictive Value of Tests
Prospective Studies
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Risk Factors
Severity of Illness Index
Stents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied 30 consecutive patients who underwent coronary stenting with respect to postprocedure endothelial dysfunction and levels of pre- and postprocedure cytokines. Patients with severe impairment of flow-mediated dependent dilation, but not flow- mediated independent dilation, had higher concentrations of C-reactive protein before percutaneous coronary intervention (12.9 ± 20.2 vs 5.6 ± 13.0 μg/ml, p = 0.04) and 24 hours after stenting (18.8 ± 20.8 vs 11.8 ± 20.0 μg/ml, p = 0.05) than patients without severe abnormities of systemic endothelial function. Thus, endothelium-dependent dilation abnormalities were related to the systemic inflammatory state, whereas endothelium-independent dilation abnormalities were not related to the inflammatory status of the patient.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2004.07.146