Adenosine primes resting stage dendritic cells before their activation

The effect of adenosine mediated suppression of immune cell activation has long been an important topic of study. While the protective benefits of such a signaling mechanism are well recognized, there remains a question as to how dendritic cells (DCs) bypass the high levels of adenosine during tissu...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2009-03, Vol.380 (4), p.748-751
Main Authors: Flach, Tracy L., Pang, Winston, Chau, Elaine M.T., Desrosiers, Melanie D., Shi, Yan
Format: Article
Language:English
Subjects:
Adenosine
Adenosine - metabolism
Animals
Cyclic AMP
Cyclic AMP - metabolism
Dendritic cells
Dendritic Cells - immunology
Immune Tolerance
Inflammation
Mice
Mice, Inbred C57BL
Receptor, Adenosine A2A - genetics
Receptor, Adenosine A2A - metabolism
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Summary:The effect of adenosine mediated suppression of immune cell activation has long been an important topic of study. While the protective benefits of such a signaling mechanism are well recognized, there remains a question as to how dendritic cells (DCs) bypass the high levels of adenosine during tissue stress and infection, and become fully activated. We report here that adenosine receptors on resting stage DCs, both in vivo and in vitro, are functionally desensitized after ligand binding. This desensitization lasts several hours during which DCs are “blind” to adenosine and are stimulated without this negative feedback. This effect is mediated by cAMP signaling. Our report suggests that there is a specific regulatory mechanism used by DCs to overcome adenosine mediated inhibition to become fully activated despite a general suppressive state.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2009.01.114