Phenomenon of life: between equilibrium and non-linearity

• Published in: Origins of life and evolution of biospheres 2004-12, Vol.34 (6), p.599-613
• Main Author: Galimov, E M
• Format: Article
• Language: English
• Subjects: Adenosine diphosphate; Adenosine Diphosphate - chemistry; Adenosine Triphosphate - chemistry; ATP; Biochemical Phenomena; Biological Evolution; Biopolymers - chemistry; Carbon Isotopes; Chemical reactions; Entropy; Equilibrium; Evolution; Evolutionary biology; Modelling; Models, Chemical; Origin of Life; Peptides; Polymers; Thermodynamics; Water consumption
• ISSN: 0169-6149; 1573-0875
• DOI: 10.1023/B:ORIG.0000043131.86328.9d

A model of ordering applicable to biological evolution is presented. It is shown that a steady state (more precisely approaching to a steady state) system of irreversible processes, under conditions of disproportionation of entropy, produces a lower-entropy product, that is, ordering. The ordering is defined as restricting of degrees of freedom: freedom of motion, interactions etc. The model differs from previous ones in that it relates the ordering to processes running not far from equilibrium, described in the linear field of non-equilibrium thermodynamics. It is shown that a system, which includes adenosine triphosphate (ATP) to adenosine diphosphate (ADP) conversion meets the demands of the physical model: it provides energy maintaining steady state conditions, and hydrolysis of ATP proceeding with consumption of water can be tightly conjugated with the most important reactions of synthesis of organic polymers (peptides, nucleotide chains etc.), which proceed with release of water. For these and other reasons ATP seems to be a key molecule of prebiotic evolution. It is argued that the elementary chemical reaction proceeding under control of an enzyme is not necessarily far from equilibrium. The experimental evidence supporting this idea, is presented. It is based on isotope data. Carbon isotope distribution in biochemical systems reveals regularity, which is inherent to steady state systems of chemical reactions, proceeding not far from equilibrium. In living organisms this feature appears at the statistical level, as many completely irreversible and non-linear processes occur in organisms. However not-far-from-equilibrium reactions are inherent to biochemical systems as a matter of principle. They are reconcilable with biochemical behavior. Extant organisms are highly evolved entities which, however, show in their basis the same features, as the simplest chemical systems must have had been involved in the origin of life. Some consequences following from the model, which may be significant for understanding the origin of life and the mechanism of biological evolution, are pointed out.