Human papilloma virus infection prior to coitarche

Objective The aim of our study was to determine the prevalence and the natural course of anogenital human papilloma virus (HPV) infections in girls prior to coitarche attending an outpatient gynecological unit. Study Design Specimens were taken from the anogenital region of 114 unselected 4-15 year...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2009-05, Vol.200 (5), p.487.e1-487.e5
Main Authors: Doerfler, Daniela, MD, Bernhaus, Astrid, MD, MSc, Kottmel, Andrea, MD, Sam, Christine, MD, Koelle, Dieter, MD, MSc, Joura, Elmar A., MD
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Child
Child, Preschool
children
DNA, Viral - analysis
Female
Follow-Up Studies
girls
Gynecology. Andrology. Obstetrics
human papilloma virus
Humans
Infectious diseases
Medical sciences
Obstetrics and Gynecology
Papillomaviridae - genetics
Papillomaviridae - isolation & purification
Papillomavirus Infections - epidemiology
persistence
Prevalence
Risk Factors
Sexual Abstinence
Uterine Cervical Diseases - epidemiology
Uterine Cervical Diseases - virology
Viral diseases
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Summary:Objective The aim of our study was to determine the prevalence and the natural course of anogenital human papilloma virus (HPV) infections in girls prior to coitarche attending an outpatient gynecological unit. Study Design Specimens were taken from the anogenital region of 114 unselected 4-15 year old girls who were referred consecutively for various gynecological problems. Results Four girls were excluded because of sexual abuse. Low-risk HPV-deoxyribonucleic acid (DNA) was detected in 4 girls (3.6%) and high-risk HPV DNA in 15 children (13.6%). Two girls testing positive for HPV DNA had clinical apparent warts. After 1 year, 2 children had persistent high-risk HPV DNA, and in 1 case we found a switch from high-risk to low-risk HPV DNA. Conclusion Subclinical genital low- and high-risk HPV infections are common in girls without any history of sexual abuse or sexual activity. We found persistence of genital HPV infection in children, which could be a reservoir for HPV-associated diseases later in life.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2008.12.028