FibroScan Evaluation of Liver Fibrosis in Liver Transplantation

Abstract Introduction Liver biopsy remains the gold standard to evaluate fibrosis. However, it is invasive and uncomfortable as well as associated with complications. Transient elastography (FibroScan) is a simple and noninvasive method to assess liver fibrosis by measuring liver stiffness in kilopa...

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Bibliographic Details
Published in:Transplantation proceedings 2009-04, Vol.41 (3), p.1044-1046
Main Authors: Sánchez Antolin, G, Garcia Pajares, F, Vallecillo, M.A, Fernandez Orcajo, P, Gómez de la Cuesta, S, Alcaide, No, Gonzalez Sagrado, M, Velicia, R, Caro-Patón, A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopsy
Body Mass Index
Elasticity Imaging Techniques - methods
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver Cirrhosis - diagnosis
Liver Cirrhosis - pathology
Liver Transplantation - adverse effects
Liver, biliary tract, pancreas, portal circulation, spleen
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Obesity - epidemiology
Obesity - pathology
Other diseases. Semiology
Prognosis
Prospective Studies
Reproducibility of Results
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Tissue, organ and graft immunology
Weight Gain
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Summary:Abstract Introduction Liver biopsy remains the gold standard to evaluate fibrosis. However, it is invasive and uncomfortable as well as associated with complications. Transient elastography (FibroScan) is a simple and noninvasive method to assess liver fibrosis by measuring liver stiffness in kilopascals. Body mass index (BMI) greater than 28 is associated with high rates of invalid tests. Liver transplant patients show increased rates of obesity. We do not yet have many data about the usefulness of FibroScan in liver transplantation. Aims To analyze the applicability of FibroScan to assess fibrosis in liver transplantation and study the association between obesity and valid tests. Material and Methods We prospectively assessed the performance of transient elastography in 29 liver transplant patients from February to May 2008. We prospectively studied the success rate, the elasticity (stiffness) in kilopascals, and the BMI. Results The BMI was greater than 30 kg/m2 in four patients; 25 to 30 kg/m2 in eight; and 17 had BMI < 25 kg/m2 . The overall success of FibroScan was 24/29 (82.7%). However, among patients with BMI > 30 kg/m2 , it was 2/4 (50%), whereas for BMI
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2009.02.027