Preserved residual renal function is associated with lower oxidative stress in peritoneal dialysis patients

Background. Residual renal function (RRF) correlates with survival in peritoneal dialysis (PD). We investigated the association between oxidative stress and RRF in PD. Methods. Adequacy of dialysis, total and free malondialdehydes (MDA), and lipid hydroperoxides (LHP) were obtained from 23 stable PD...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2009-05, Vol.24 (5), p.1685-1689
Main Authors: Ignace, Sophie, Fouque, Denis, Arkouche, Walid, Steghens, Jean-Paul, Guebre-Egziabher, Fitsum
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Cross-Sectional Studies
Emergency and intensive care: renal failure. Dialysis management
Female
Humans
inflammation
Intensive care medicine
Kidney - physiology
Kidney Diseases - physiopathology
Kidney Diseases - therapy
lipid peroxidation
Lipid Peroxidation - physiology
Lipid Peroxides - blood
Male
Malondialdehyde - blood
Medical sciences
Middle Aged
Multivariate Analysis
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
oxidative stress
Oxidative Stress - physiology
Peritoneal Dialysis
Renal failure
residual renal function
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Summary:Background. Residual renal function (RRF) correlates with survival in peritoneal dialysis (PD). We investigated the association between oxidative stress and RRF in PD. Methods. Adequacy of dialysis, total and free malondialdehydes (MDA), and lipid hydroperoxides (LHP) were obtained from 23 stable PD patients. Results. Free MDA level decreased with total weekly Kt/ V urea (r = −0.51, P = 0.013) and urinary Kt/V (KRU) (r = −0.53, P = 0.009), but not with peritoneal Kt/V. Similar results were found with LHP level. In multivariate analysis, total weekly Kt/V urea and KRU remained associated with free MDA and LHP, independently of gender, nutritional or inflammatory status, and peritoneal permeability. Conclusion. A preserved RRF is associated with lower serum levels of lipid peroxidation products among PD patients.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfp077