Cerebral oxygen desaturation is associated with early postoperative neuropsychological dysfunction in patients undergoing cardiac surgery

• Published in: Journal of cardiothoracic and vascular anesthesia 2004-10, Vol.18 (5), p.552-558
• Main Authors: Yao, Fun-Sun F., Tseng, Chia-Chih A., Ho, Chee-Yueh A., Levin, Serle K., Illner, Pavel
• Format: Article
• Language: English
• Subjects: Aged; Brain - blood supply; cardiac surgery; Cardiac Surgical Procedures - adverse effects; Cardiopulmonary Bypass - adverse effects; cerebral oxygen saturation; Cognition Disorders - diagnosis; Cognition Disorders - etiology; Female; Humans; Male; Monitoring, Intraoperative - methods; Neurologic Examination - methods; neuropsychological outcome; Neuropsychological Tests; Oxygen - blood; Oxygen - metabolism; Postoperative Complications - diagnosis; Predictive Value of Tests; Prospective Studies; Time Factors
• ISSN: 1053-0770; 1532-8422
• DOI: 10.1053/j.jvca.2004.07.007

Objective: To evaluate the relationship between cerebral oxygen saturation and neuropsychological dysfunction after cardiac surgery. Design: Prospective and observational study. Setting: Operating room and cardiac floor of a university hospital. Participants: One hundred one patients undergoing elective cardiac surgery with cardiopulmonary bypass Intervention: Bilateral noninvasive cerebral oxygen saturations were monitored over the forehead. The anesthetic and surgical techniques were performed as usual, and no interventions were attempted based on the monitor. Neuropsychological outcome was assessed by the Mini-Mental State Examination (MMSE) and the antisaccadic eye movement test (ASEM). Measurements and Main Results: Preoperative baseline values of cerebral oxygen saturation (rSO 2) were 58.6% ± 10.2%. Patients with the nadir rSO 2