Expression of interleukin-11 receptor α and interleukin-11 protein in the endometrium of normal fertile women and women with recurrent miscarriage

Interleukin-11 (IL-11) is a member of the IL-6 family of cytokines. Previous studies have suggested that IL-11 may play a role in human endometrial function. In this study, we have used immunocytochemistry to compare endometrial IL-11Rα and IL-11 expression in precisely timed peri-implantation biops...

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Bibliographic Details
Published in:Journal of reproductive immunology 2004-12, Vol.64 (1), p.145-155
Main Authors: Linjawi, S., Li, T.C., Tuckerman, E.M., Blakemore, A.I.F., Laird, S.M.
Format: Article
Language:English
Subjects:
Abortion, Habitual - immunology
Abortion, Habitual - pathology
Adult
Cytokines
Endometrium
Endometrium - immunology
Endometrium - pathology
Epithelium - immunology
Epithelium - pathology
Female
Gene Expression Regulation - immunology
Humans
IL-11
Interleukin-11 - biosynthesis
Interleukin-11 Receptor alpha Subunit
Pregnancy
Receptors, Interleukin - biosynthesis
Receptors, Interleukin-11
Recurrent miscarriage
Stromal Cells - immunology
Stromal Cells - pathology
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Summary:Interleukin-11 (IL-11) is a member of the IL-6 family of cytokines. Previous studies have suggested that IL-11 may play a role in human endometrial function. In this study, we have used immunocytochemistry to compare endometrial IL-11Rα and IL-11 expression in precisely timed peri-implantation biopsies from 9 normal fertile women and 16 recurrent miscarriage (RM) women. Immunocytochemistry was semi-quantified by obtaining an H-score value, which showed increased expression of both IL-11 and IL-11Rα in epithelial cells compared to stromal cells in all biopsies. There was a significant ( P < 0.01) reduction in epithelial cell IL-11, but not stromal cell IL-11, expression in endometrium from RM women compared to normal fertile women. There were no significant differences in expression of IL-11Rα protein in both stromal and epithelial cells in endometrium from the two groups of women. This work shows the presence of IL-11 and IL-11Rα within the endometrium of RM women during the peri-implantation period. The decreased expression of IL-11 in epithelial endometrium in RM women suggests that this cytokine may play a role in preventing miscarriage.
ISSN:0165-0378
1872-7603
DOI:10.1016/j.jri.2004.08.007