Low Level of Low-Density Lipoprotein Cholesterol Increases Hemorrhagic Transformation in Large Artery Atherothrombosis but Not in Cardioembolism

Low cholesterol level is known to be associated with increased cerebral hemorrhage. However, the associations of hemorrhagic transformation (HTf) after acute ischemic stroke and the low levels of total cholesterol (TC) or low-density lipoprotein cholesterol (LDLC) are largely undiscovered. Of the 10...

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Bibliographic Details
Published in:Stroke (1970) 2009-05, Vol.40 (5), p.1627-1632
Main Authors: BEOM JOON KIM, LEE, Seung-Hoon, RYU, Wi-Sun, BONG SU KANG, CHI KYUNG KIM, YOON, Byung-Woo
Format: Article
Language:English
Subjects:
Aged
Atherosclerosis - blood
Atherosclerosis - pathology
Biological and medical sciences
Brain Ischemia - complications
Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges
Cerebral Hemorrhage - pathology
Cholesterol - blood
Cholesterol, LDL - blood
Disease Progression
Female
Fundamental and applied biological sciences. Psychology
Humans
Intracranial Embolism - blood
Intracranial Embolism - pathology
Intracranial Thrombosis - blood
Intracranial Thrombosis - pathology
Lipoproteins, LDL - blood
Logistic Models
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Neurology
Stroke - blood
Stroke - etiology
Stroke - pathology
Triglycerides - blood
Vascular diseases and vascular malformations of the nervous system
Vertebrates: nervous system and sense organs
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Summary:Low cholesterol level is known to be associated with increased cerebral hemorrhage. However, the associations of hemorrhagic transformation (HTf) after acute ischemic stroke and the low levels of total cholesterol (TC) or low-density lipoprotein cholesterol (LDLC) are largely undiscovered. Of the 1034 patients with acute ischemic stroke who were consecutively admitted to our hospital, 377 patients with stroke attributable to large artery atherothrombosis (LAA; n=210) or cardioembolism (n=167) were selected for this study. Demographic and clinical information was collected and HTf was evaluated through follow-up T2*-weighted gradient-echo MRI performed usually within 1 week after stroke. Measurement of lipid parameters included TC, LDLC, high-density lipoprotein cholesterol, and triglyceride. Of the 377 patients, HTf was noted in 74 patients (19.6%). When patients were divided into 4 groups according to their TC and LDLC levels, the incidence of HTf was significantly elevated in the lowest quartile of each TC (P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.108.539643