Immunohistochemical Detection of WT1 Protein in Endometrial Cancer

Background: The Wilms' tumor gene WT1 is overexpressed in various kinds of solid tumors. However, it remains unclear whether WT1 plays a pathophysiological role in endometrial cancer. Patients and Methods: A series of 70 endometrial cancer patients who had undergone a curative resection was stu...

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Bibliographic Details
Published in:Anticancer research 2009-05, Vol.29 (5), p.1691-1695
Main Authors: OHNO, Satoshi, DOHI, Satoshi, OHNO, Yumiko, KYO, Satoru, SUGIYAMA, Haruo, SUZUKI, Nobutaka, INOUE, Masaki
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Endometrial Neoplasms - metabolism
Endometrial Neoplasms - pathology
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Medical sciences
Middle Aged
Tumors
WT1 Proteins - metabolism
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Summary:Background: The Wilms' tumor gene WT1 is overexpressed in various kinds of solid tumors. However, it remains unclear whether WT1 plays a pathophysiological role in endometrial cancer. Patients and Methods: A series of 70 endometrial cancer patients who had undergone a curative resection was studied to determine the correlation between WT1 expression, clinicopathological characteristics and prognosis. Tissue specimens were evaluated for WT1 expression by immunohistochemistry. Results: The expression of WT1 was strong in 31 patients (44%) and weak in 39 patients (56%). WT1 overexpression was associated with advanced FIGO stage (p=0.0266), myometrial invasion (p=0.0477) and high-grade histological differentiation (p=0.0049). The expression level of WT1 was found to be a significant predictor of disease relapse in univariate analysis (p=0.0233), but not in multivariate analysis (p=0.4757). Conclusion: These results suggested that tumor-produced WT1 provided additional prognostic information in endometrial cancer patients.
ISSN:0250-7005
1791-7530