Bacterial Translocation in the Normal Human Appendix Parallels the Development of the Local Immune System

: Experimental modes and pathological conditions may result in bacterial translocation (BT), that is, the passage of indigenous bacteria colonizing the intestine through the intestinal mucosa to mesenteric lymph nodes. Yet no data are available on BT in the normal human gut. We determined the occurr...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2004-12, Vol.1029 (1), p.337-343
Main Authors: GEBBERS, JAN-OLAF, LAISSUE, JEAN-ALBERT
Format: Article
Language:English
Subjects:
Adolescent
Adult
Appendix - immunology
Appendix - microbiology
Appendix - ultrastructure
Bacteria
Bacteria - isolation & purification
bacterial translocation
Bacterial Translocation - immunology
Breast Feeding
Child
Child, Preschool
GALT
human vermiform appendix
Humans
Immunity, Mucosal
Infant
Infant, Newborn
Intestinal Mucosa - microbiology
Middle Aged
postnatal development
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Summary:: Experimental modes and pathological conditions may result in bacterial translocation (BT), that is, the passage of indigenous bacteria colonizing the intestine through the intestinal mucosa to mesenteric lymph nodes. Yet no data are available on BT in the normal human gut. We determined the occurrence of BT and its extent in histologically normal, incidentally removed human vermiform appendices (VA) from individuals of different ages and correlated the findings with the development with age of associated lymphatic tissue. BT appears to pertain to normal antigen‐sampling processes of the GALT in the VA. It also parallels the development of the GALT and its maintenance during adulthood. In the first two weeks after birth, when bacterial colonization of the gut evolves and when the VA lacks the protection of secretory IgA, BT was not detected. Thereafter, BT occurs along with development of the local GALT, which is fully built up after the first year. A physiological uptake of, or invasion by, bacteria may be instrumental (1) for tolerance induction against the indigenous flora and (2) for the stimulation and normal development of the GALT.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1309.015