Depression and C-reactive protein: population-based Health 2000 Study

To test whether depression is independently associated with elevated levels of C-reactive protein (CRP) in a large nationwide population-based sample. Depression and CRP were assessed in 6005 Finns aged >30 years, as part of the ongoing population-based Health 2000 Study. Depression was determine...

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Bibliographic Details
Published in:Psychosomatic medicine 2009-05, Vol.71 (4), p.423-430
Main Authors: Elovainio, Marko, Aalto, Anna-Mari, Kivimäki, Mika, Pirkola, Sami, Sundvall, Jouko, Lönnqvist, Jouko, Reunanen, Antti
Format: Article
Language:English
Subjects:
Biomarkers
Blood Glucose - analysis
C-reactive protein
C-Reactive Protein - analysis
Confounding Factors (Epidemiology)
Depression
Depression - blood
Depression - epidemiology
Depressive Disorder - blood
Depressive Disorder - epidemiology
Diagnostic testing
Elderly people
Female
Finland - epidemiology
Gender differences
Health
Health Behavior
Health Surveys
Humans
Inflammation - blood
Inflammation - etiology
Lipids - blood
Male
Men
Mental depression
Middle Aged
Obesity - epidemiology
Proteins
Psychosomatic medicine
Risk factors
Severity of Illness Index
Smoking - epidemiology
Socioeconomic Factors
Surveys and Questionnaires
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Summary:To test whether depression is independently associated with elevated levels of C-reactive protein (CRP) in a large nationwide population-based sample. Depression and CRP were assessed in 6005 Finns aged >30 years, as part of the ongoing population-based Health 2000 Study. Depression was determined by responses to the Beck's Depression Inventory (BDI-21) and by Composite International Diagnostic Interview (CIDI). Higher scores on BDI-21 were related to higher CRP levels (beta = 0.12, p < .001) in men and (beta = 0.08, p < .001) in women. In men, but not in women, this relationship persisted after adjustment for a number of other known risk factors. In men, the more recent dysthymic disorder or at least moderate depressive episode defined using CIDI was related to elevated CRP levels (beta = 0.06, p = .006). Depressive symptoms may be partly responsible for inflammatory processes, and inflammatory processes may induce depressive symptoms in men.
ISSN:0033-3174
1534-7796
DOI:10.1097/psy.0b013e31819e333a