Neurobiology of migraine

Abstract Migraine is a complex disorder of the brain whose mechanisms are only now being unraveled. It is common, disabling and economically costly. The pain suggests an important role of the nociceptive activation, or the perception of activation, of trigeminal cranial, particularly intracranial af...

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Bibliographic Details
Published in:Neuroscience 2009-06, Vol.161 (2), p.327-341
Main Authors: Goadsby, P.J, Charbit, A.R, Andreou, A.P, Akerman, S, Holland, P.R
Format: Article
Language:English
Subjects:
Afferent Pathways - pathology
Afferent Pathways - physiopathology
Animals
Biological and medical sciences
Blood Proteins - metabolism
Brain - blood supply
Brain - physiopathology
brainstem
Capillary Permeability
dopamine
Electric Stimulation Therapy
Fundamental and applied biological sciences. Psychology
glutamate
Humans
migraine
Migraine Disorders - pathology
Migraine Disorders - physiopathology
Migraine Disorders - therapy
Neurology
Nociceptors - metabolism
orexin
Pain - pathology
Pain - physiopathology
Receptors, G-Protein-Coupled - physiology
Receptors, Glutamate - physiology
trigeminal
Trigeminal Nuclei - physiology
Vertebrates: nervous system and sense organs
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Summary:Abstract Migraine is a complex disorder of the brain whose mechanisms are only now being unraveled. It is common, disabling and economically costly. The pain suggests an important role of the nociceptive activation, or the perception of activation, of trigeminal cranial, particularly intracranial afferents. Moreover, the involvement of a multi-sensory disturbance that includes light, sound and smells, as well as nausea, suggests the problem may involve central modulation of afferent traffic more broadly. Brain imaging studies in migraine point to the importance of sub-cortical structures in the underlying pathophysiology of the disorder. Migraine may thus be considered an inherited dysfunction of sensory modulatory networks with the dominant disturbance affecting abnormal processing of essentially normal neural traffic.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2009.03.019