Evolution of hyperacute stroke over 6 hours using serial MR perfusion and diffusion maps

Purpose To develop an appropriate method to evaluate the time‐course of diffusion and perfusion changes in a clinically relevant animal model of ischemic stroke and to examine lesion progression on MR images. An exploration of acute stroke infarct expansion was performed in this study by using a new...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2009-06, Vol.29 (6), p.1262-1270
Main Authors: Harris, Ashley D., Kosior, Robert K., Chen, Henry S., Andersen, Linda B., Frayne, Richard
Format: Article
Language:English
Subjects:
acute ischemic stroke
Animals
Brain Mapping - methods
Cerebrovascular Circulation
Contrast Media
Diffusion Magnetic Resonance Imaging - methods
diffusion-perfusion mismatch
diffusion-weighted imaging
Disease Models, Animal
Disease Progression
Dogs
Gadolinium DTPA
Image Processing, Computer-Assisted
perfusion-weighted imaging
Stroke - pathology
Time Factors
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Summary:Purpose To develop an appropriate method to evaluate the time‐course of diffusion and perfusion changes in a clinically relevant animal model of ischemic stroke and to examine lesion progression on MR images. An exploration of acute stroke infarct expansion was performed in this study by using a new methodology for developing time‐to‐infarct maps based on the time at which each voxel becomes infarcted. This enabled definition of homogeneous regions from the heterogeneous stroke infarct. Materials and Methods Time‐to‐infarct maps were developed based on apparent diffusion coefficient (ADC) changes. These maps were validated and then applied to blood flow and time‐to‐peak maps to examine perfusion changes. Results ADC stroke infarct showed different evolution patterns depending on the time at which that region of tissue infarcted. Applying the time‐to‐infarct maps to the perfusion maps showed localized perfusion evolution characteristics. In some regions, perfusion was immediately affected and showed little change over the experiment; however, in some regions perfusion changes were more dynamic. Conclusion Results were consistent with the diffusion‐perfusion mismatch hypothesis. In addition, characteristics of collateral recruitment were identified, which has interesting stroke pathophysiology and treatment implications. J. Magn. Reson. Imaging 2009;29:1262–1270. © 2009 Wiley‐Liss, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.21763