Modulation of porosity in apatitic cements by the use of α-tricalcium phosphate—calcium sulphate dihydrate mixtures

• Published in: Biomaterials 2005-06, Vol.26 (17), p.3395-3404
• Main Authors: Fernández, Enrique, Vlad, Maria Daniela, Gel, Maria Montserrat, López, Jose, Torres, Ricardo, Cauich, Juan V., Bohner, Marc
• Format: Article
• Language: English
• Subjects: Apatites - analysis; Apatites - chemistry; Bone Cements - analysis; Bone Cements - chemistry; Calcium phosphate; Calcium Phosphates - analysis; Calcium Phosphates - chemistry; Calcium Sulfate - analysis; Calcium Sulfate - chemistry; Calcium sulphate; Cement; Complex Mixtures - analysis; Complex Mixtures - chemistry; Compressive Strength; Hardness; Materials Testing; Physico-chemical properties; Porosity; Powders; Surface Properties
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/j.biomaterials.2004.09.023

Calcium phosphate bone cements are injectable biomaterials that are being used in dental and orthopaedic applications through minimally invasive surgery techniques. Nowadays, apatitic bone cements based on α-tricalcium phosphate ( α-TCP) are of special interest due to their self-setting behaviour when mixed with an aqueous liquid phase. In this study, a new method to improve osteointegration of α-TCP-based cements is presented. This method consists in the modification of the cement's powder phase with different amounts of calcium sulphate dihydrate (CSD). The resulting hardening properties of the new biphasic cements are a combination between the progressive hardening due to the main α-TCP reactant and the progressive dissolution of the CSD phase, which render a porous material. It was observed that the maximum compressive strength of Biocement-H © (45 MPa) decreased as the amount of CSD increased in the cement powder mixture (≈30 MPa for 25 wt% of CSD). It was also observed that after complete dissolution of the CSD phase a porous apatitic structure appears with a mechanical compressive strength suitable for cancellous bone applications (10 MPa).