The role of interleukin-6 and transforming growth factor-beta1 in predicting restenosis within stented infarct-related artery

Despite high efficacy of percutaneous coronary intervention (PCI), in-stent restenosis proves to be a significant problem of therapy. Restenosis concerns around 30 percent of patients. Studies have suggested that restenosis is initiated by cells which participate in intense inflammatory reaction cau...

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Bibliographic Details
Published in:International journal of immunopathology and pharmacology 2009-04, Vol.22 (2), p.493-500
Main Authors: Szkodzinski, J, Blazelonis, A, Wilczek, K, Hudzik, B, Romanowski, W, Gasior, M, Wojnar, R, Lekston, A, Polonski, L, Zubelewicz-Szkodzinska, B
Format: Article
Language:English
Subjects:
Adult
Aged
Angioplasty, Balloon, Coronary - adverse effects
Angioplasty, Balloon, Coronary - instrumentation
Biomarkers - blood
Coronary Angiography
Coronary Restenosis - diagnostic imaging
Coronary Restenosis - etiology
Coronary Restenosis - immunology
Coronary Vessels - immunology
Coronary Vessels - pathology
Female
Humans
Interleukin-6 - blood
Male
Middle Aged
Myocardial Infarction - therapy
Predictive Value of Tests
ROC Curve
Sensitivity and Specificity
Severity of Illness Index
Stents
Time Factors
Transforming Growth Factor beta1 - blood
Treatment Outcome
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Summary:Despite high efficacy of percutaneous coronary intervention (PCI), in-stent restenosis proves to be a significant problem of therapy. Restenosis concerns around 30 percent of patients. Studies have suggested that restenosis is initiated by cells which participate in intense inflammatory reaction caused by stent implantation. Atherosclerotic plaque rupture during stent implantation and PCI-associated injury of the vessel wall lead to hemorrhage and release of various cytokines. They are probably responsible for quick recurrence of vascular lumen stenosis (restenosis). Interleukin-6 (IL-6) is known as a main pro-inflammatory cytokine, whereas Transformig Growth Factor-beta1 (TGF-beta1) has anti-inflammatory properties. The study population comprised 36 patients with myocardial infarction treated with PCI with stent implantation. They underwent control coronary angiography after 12 months. At this time plasma concentration of IL-6 and TGF-beta was measured in peripheral blood. Serum IL-6 concentration in the analyzed population correlates with lumen loss (p
ISSN:0394-6320