The autologous serum skin test in the follow‐up of patients with chronic urticaria

Background:  The presence of anti‐FcεRI and anti‐IgE autoantibodies in a subset of patients with chronic urticaria suggests their aetiopathogenetic role. In clinical practice, the presence of these antibodies is usually considered when the autologous serum skin test (ASST) is positive. Aims:  To eva...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2005-02, Vol.60 (2), p.256-258
Main Authors: Fusari, A., Colangelo, C., Bonifazi, F., Antonicelli, L.
Format: Article
Language:English
Subjects:
Adult
Allergic diseases
Allergies
Autoantibodies - blood
autoimmune thyroiditis
autologous serum skin test
Biological and medical sciences
Case-Control Studies
Chronic Disease
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunoglobulins
Immunopathology
Iodide Peroxidase - immunology
Male
Medical sciences
Medical screening
Middle Aged
Skin allergic diseases. Stinging insect allergies
Skin Tests - methods
Thyroiditis, Autoimmune - complications
Thyroiditis, Autoimmune - immunology
Time Factors
urticaria
Urticaria - blood
Urticaria - complications
Urticaria - diagnosis
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Summary:Background:  The presence of anti‐FcεRI and anti‐IgE autoantibodies in a subset of patients with chronic urticaria suggests their aetiopathogenetic role. In clinical practice, the presence of these antibodies is usually considered when the autologous serum skin test (ASST) is positive. Aims:  To evaluate if the positive ASST follows up the activity of chronic urticaria. Methods:  Autologous serum skin test and thyroid autoantibody detection were performed in 82 patients with chronic urticaria and repeated 1 year later, when the vast majority of patients were symptom‐free. Twenty patients with Hashimoto thyroiditis (HT), who had never suffered from urticaria, represented the control group. Results:  At the start of the study, the prevalence of positive ASST was 46.6%. The association of HT–urticaria was 29.3%. ASST was positive in 62 and 39% of patients with and without HT, respectively (P > 0.05 ns). One year later, 28 of 34 patients with a positive ASST were symptom‐free, but 50% of them were positive for ASST. The ASST was positive in 86.7 and 8% of patients with and without HT, respectively (P 
ISSN:0105-4538
1398-9995
DOI:10.1111/j.1398-9995.2005.00673.x