Blood Pressure Response to Strength Training May Be Influenced by Angiotensinogen A-20C and Angiotensin II Type I Receptor A1166C Genotypes in Older Men and Women

Objectives: To determine the influence of angiotensinogen (AGT) A–20C, M235 T, and angiotensin II type 1 receptor (AGTR1) A1166C genotypes on resting blood pressure (BP) response to strength training (ST) in older men and women. Design: Prospective intervention study with retrospective genotyping. S...

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Bibliographic Details
Published in:Journal of the American Geriatrics Society (JAGS) 2005-02, Vol.53 (2), p.204-210
Main Authors: Delmonico, Matthew J., Ferrell, Robert E., Meerasahib, Anish, Martel, Greg F., Roth, Stephen M., Kostek, Matthew C., Hurley, Ben F.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
aging
Angiotensinogen - genetics
Biological and medical sciences
Blood pressure
Blood Pressure - genetics
Body Composition
Exercise
Exercise - physiology
Female
General aspects
Genotype
Genotype & phenotype
Humans
hypertension
Male
Medical sciences
Middle Aged
Muscle, Skeletal - physiology
Older people
Physical Endurance - genetics
Polymorphism, Genetic
Proteins
Receptor, Angiotensin, Type 1 - genetics
single nucleotide polymorphism
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Summary:Objectives: To determine the influence of angiotensinogen (AGT) A–20C, M235 T, and angiotensin II type 1 receptor (AGTR1) A1166C genotypes on resting blood pressure (BP) response to strength training (ST) in older men and women. Design: Prospective intervention study with retrospective genotyping. Setting: University of Maryland Exercise Physiology Laboratory. Participants: Seventy sedentary, healthy older men (n=34) and women (n=36). Intervention: Approximately 23 weeks of ST performed 3 days per week. Measurements: Resting BP was measured on six separate occasions before and after ST for each subject. AGT and AGTR1 genotyping was performed retrospectively from each subject's genomic deoxyribonucleic acid. Results: Systolic BP decreased in C‐allele carriers at the AGT A–20C locus with ST (122±1 to 116±2 mmHg, P
ISSN:0002-8614
1532-5415
DOI:10.1111/j.1532-5415.2005.53104.x