Evolution of microRNAs located within Hox gene clusters

MicroRNAs (miRNAs) form an abundant class of non‐coding RNA genes that have an important function in post‐transcriptional gene regulation and in particular modulate the expression of developmentally important transcription factors including Hox genes. Two families of microRNAs are genomically locate...

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Published in:Journal of experimental zoology. Part B, Molecular and developmental evolution Molecular and developmental evolution, 2005-01, Vol.304B (1), p.75-85
Main Authors: Tanzer, Andrea, Amemiya, Chris T., Kim, Chang-Bae, Stadler, Peter F.
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Biological Evolution
Gene Expression Regulation - genetics
Genes, Homeobox
Homeodomain Proteins - genetics
MicroRNAs - genetics
MicroRNAs - metabolism
Molecular Sequence Data
Multigene Family - genetics
Multigene Family - physiology
Transcription, Genetic - genetics
Transcription, Genetic - physiology
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Summary:MicroRNAs (miRNAs) form an abundant class of non‐coding RNA genes that have an important function in post‐transcriptional gene regulation and in particular modulate the expression of developmentally important transcription factors including Hox genes. Two families of microRNAs are genomically located in intergenic regions in the Hox clusters of vertebrates. Here we describe their evolution in detail. We show that the micro RNAs closely follow the patterns of protein evolution in the Hox clusters, which is characterized by cluster duplications followed by differential gene loss. J. Exp. Zool. (Mol. Dev. Evol.) 304B: 1–10, 2005. © 2005 Wiley‐Liss, Inc.
ISSN:1552-5007
1552-5015
DOI:10.1002/jez.b.21021