ATG induction therapy: long‐term effects on Th1 but not on Th2 responses

Summary Antithymocyte globulin (ATG) induction therapy is associated with an increased long‐term risk of infection‐ and cancer‐related death. To analyze long‐term effects of ATG induction on lymphocyte function, we prospectively assessed CD4 helper function, B‐cell/monocyte and cytokine responses in...

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Bibliographic Details
Published in:Transplant international 2005-02, Vol.18 (2), p.226-236
Main Authors: Weimer, Rolf, Staak, Anne, Süsal, Caner, Streller, Sabine, Yildiz, Sevgi, Pelzl, Steffen, Renner, Fabrice, Dietrich, Hartmut, Daniel, Volker, Rainer, Lucy, Kamali‐Ernst, Shirin, Ernst, Wolfgang, Padberg, Winfried, Opelz, Gerhard
Format: Article
Language:English
Subjects:
acute rejection
adhesion molecules
Adult
Antilymphocyte Serum - adverse effects
Antilymphocyte Serum - pharmacology
antithymocyte globulin
B-Lymphocytes - immunology
Biological and medical sciences
CD4 Lymphocyte Count
Cell Adhesion Molecules - biosynthesis
cytokines
Cytokines - biosynthesis
Female
General aspects
Graft Rejection - prevention & control
Humans
In Vitro Techniques
Infection - etiology
Ki-1 Antigen - blood
kidney transplantation
Kidney Transplantation - immunology
Lymphoproliferative Disorders - etiology
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Pharmacology. Drug treatments
Prospective Studies
Receptors, Cytokine - biosynthesis
Th1 Cells - immunology
Th1/Th2 response
Th2 Cells - immunology
Time Factors
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Summary:Summary Antithymocyte globulin (ATG) induction therapy is associated with an increased long‐term risk of infection‐ and cancer‐related death. To analyze long‐term effects of ATG induction on lymphocyte function, we prospectively assessed CD4 helper function, B‐cell/monocyte and cytokine responses in 84 renal transplant recipients (ATG, n = 44) up to 1 year post‐transplant. A PWM‐driven allogeneic coculture system was used to assess helper function of CD4+ T cells and T‐cell‐dependent B‐cell responses. SAC I was used for T‐cell‐independent stimulation of B‐cell cultures. In vitro cytokine secretion and serum soluble CD30 (sCD30) were determined by enzyme‐linked immunosorbent assay (ELISA). ATG induced a persistent decrease of peripheral blood lymphocyte counts compared with non‐ATG treatment because of a predominant decrease of CD4+ T cells (4 months, 1 year; P 
ISSN:0934-0874
1432-2277
DOI:10.1111/j.1432-2277.2004.00047.x