Interaction of Helicobacter pylori with host cells: function of secreted and translocated molecules

Secreted proteins are of general interest from the perspective of bacteria–host interaction. The gastric bacterial pathogen Helicobacter pylori uses a set of secreted and translocated proteins — including outer membrane adhesins, secreted extracellular enzymes and translocated effector proteins — to...

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Bibliographic Details
Published in:Current opinion in microbiology 2005-02, Vol.8 (1), p.67-73
Main Authors: Rieder, Gabriele, Fischer, Wolfgang, Haas, Rainer
Format: Article
Language:English
Subjects:
Animals
Bacterial Proteins - metabolism
Gastric Mucosa - immunology
Gastric Mucosa - microbiology
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - metabolism
Helicobacter pylori - pathogenicity
Helicobacter pylori - physiology
Humans
Signal Transduction
Virulence Factors - metabolism
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Summary:Secreted proteins are of general interest from the perspective of bacteria–host interaction. The gastric bacterial pathogen Helicobacter pylori uses a set of secreted and translocated proteins — including outer membrane adhesins, secreted extracellular enzymes and translocated effector proteins — to adapt to its extraordinary habitat, the gastric mucosa. Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system and its translocated effector protein, cytotoxin-associated antigen A (CagA). VacA targets not only epithelial cells, but also cells of the immune system and induces immunosuppression. CagA has been shown to interact with a growing set of eucaryotic signaling molecules in phosphorylation-dependent and -independent ways.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2004.12.004