Can peak systolic velocities be used for prediction of stroke in sickle cell anemia?

Ischemic stroke occurs in at least 11% of patients with homozygous sickle cell anemia (SCD) by the time they turn 20 years old. High risk associated with distal intracranial internal carotid (ICA) and proximal middle cerebral artery (MCA) stenosis can be detected by transcranial Doppler (TCD). TCD s...

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Bibliographic Details
Published in:Pediatric radiology 2005-01, Vol.35 (1), p.66-72
Main Authors: Jones, Anne, Granger, Suzanne, Brambilla, Don, Gallagher, Dianne, Vichinsky, Elliott, Woods, Gerald, Berman, Brian, Roach, Steve, Nichols, Fenwick, Adams, Robert J
Format: Article
Language:English
Subjects:
Adolescent
Anemia, Sickle Cell - complications
Blood Flow Velocity - physiology
Child
Child, Preschool
Cohort Studies
Humans
Predictive Value of Tests
Stroke - diagnostic imaging
Stroke - etiology
Ultrasonography, Doppler, Transcranial
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Summary:Ischemic stroke occurs in at least 11% of patients with homozygous sickle cell anemia (SCD) by the time they turn 20 years old. High risk associated with distal intracranial internal carotid (ICA) and proximal middle cerebral artery (MCA) stenosis can be detected by transcranial Doppler (TCD). TCD screening offers the possibility of reducing the risk of first stroke significantly based on a paradigm tested and proven to be effective in a stroke prevention trial in sickle cell anemia (STOP). Children with high flow velocity in the ICA and MCA of 200 cm/s time average mean of the maximum (TAMM) or higher had a 10% per year risk of first stroke that was reduced to
ISSN:0301-0449
1432-1998
DOI:10.1007/s00247-004-1282-9