Functional magnetic resonance imaging studies of schizophrenic patients during word production: effects of d-cycloserine

The objective of the present study was to examine patterns of cortical activation underlying d-cycloserine's therapeutic efficacy in schizophrenic patients using functional magnetic resonance imaging (fMRI). We measured frontal and temporal lobe activation following a word fluency task in 12 su...

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Bibliographic Details
Published in:Psychiatry research 2005-01, Vol.138 (1), p.23-31
Main Authors: Yurgelun-Todd, Deborah A., Coyle, Joseph T., Gruber, Staci A., Renshaw, Perry F., Silveri, Marisa M., Amico, Edward, Cohen, Bruce, Goff, Donald C.
Format: Article
Language:English
Subjects:
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - therapeutic use
Cerebral Cortex - metabolism
Cycloserine - administration & dosage
Cycloserine - therapeutic use
d-cycloserine
Diagnostic and Statistical Manual of Mental Disorders
Double-Blind Method
Drug Therapy, Combination
Female
fMRI
Humans
Magnetic Resonance Imaging
Male
Negative symptoms
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - drug therapy
Speech
Temporal Lobe - metabolism
Verbal Behavior
Verbal fluency
Vocabulary
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Summary:The objective of the present study was to examine patterns of cortical activation underlying d-cycloserine's therapeutic efficacy in schizophrenic patients using functional magnetic resonance imaging (fMRI). We measured frontal and temporal lobe activation following a word fluency task in 12 subjects meeting DSM-IV criteria for schizophrenia at baseline and after 8 weeks of supervised treatment, using a double-blind, placebo-controlled design. Half of the patients received d-cycloserine ( n=6) as a supplement to their conventional neuroleptic treatment while the other half ( n=6) was augmented with placebo. Patients receiving d-cycloserine, but not placebo, demonstrated a significant increase in temporal lobe activation. This increased activation was significantly associated with a reduction in negative symptoms. These results suggest that the addition of d-cycloserine to conventional neuroleptics may improve negative symptoms through enhanced temporal lobe function.
ISSN:0925-4927
0165-1781
1872-7506
DOI:10.1016/j.pscychresns.2004.11.006