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Maturation of the expression of adrenomedullin, endothelin-1 and nitric oxide synthases in adipose tissues from childhood to adulthood
OBJECTIVE: To investigate if the vasoactive systems adrenomedullin (ADM) and endothelin-1 (ET-1) are expressed in human adipose tissues in children and in adults and to determine the distribution pattern of nitric oxide synthases (NOS). DESIGN AND SUBJECTS: Subcutaneous, mesenterial and omental adip...
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| Published in: | International Journal of Obesity 2005-03, Vol.29 (3), p.275-280 |
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| Main Authors: | , , , , , , |
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| container_end_page | 280 |
| container_issue | 3 |
| container_start_page | 275 |
| container_title | International Journal of Obesity |
| container_volume | 29 |
| creator | Knerr, I Schirl, C Horbach, T Stuppy, A Carbon, R Rascher, W Dötsch, J |
| description | OBJECTIVE:
To investigate if the vasoactive systems adrenomedullin (ADM) and endothelin-1 (ET-1) are expressed in human adipose tissues in children and in adults and to determine the distribution pattern of nitric oxide synthases (NOS).
DESIGN AND SUBJECTS:
Subcutaneous, mesenterial and omental adipose tissue specimens taken from 15 children (age 0.5–16 y, median 6 y) and 13 adults (age 43–79 y, median 60 y) were analyzed. The body mass indices (BMI) were within the normal range. All patients were normotensive, and were free of infectious disease, and metabolic or endocrine disorders. The specimens were taken during elective laparotomies after informed consent was obtained.
MEASUREMENTS:
ADM, ET-1, the endothelial (eNOS) and inducible (iNOS) NOS as well as two housekeeping genes were measured using quantitative real-time PCR.
RESULTS:
ADM gene expression was found at all locations, and was significantly higher in adults than in children (
P |
| doi_str_mv | 10.1038/sj.ijo.0802885 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_67433488</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A188448397</galeid><sourcerecordid>A188448397</sourcerecordid><originalsourceid>FETCH-LOGICAL-c576t-1ccb581ba770c094cf057474a59a9fd25a5ea3d142343f8c8e444b2298c261043</originalsourceid><addsrcrecordid>eNp1kk2PFCEQhjtG446rV28assY92bNAQ0MfNxu_kjVe9EwYunqHSQ-MFJ3s_gF_t4zTOmrWcACK5y2q4K2q54wuGW30BW6WfhOXVFOutXxQLZhQbS1Fpx5WC9pQVVPZypPqCeKGUiol5Y-rEyZbxRnVi-r7J5unZLOPgcSB5DUQuN0lQJwjtk8Q4hb6aRx9eEMg9LFQZV0zYkNPgs_JOxJvfQ8E70JeWwQkPhSp30UEkj3iVEJDilvi1n7s1zH2JMdCTGPeb55WjwY7Ijyb59Pq67u3X64-1Nef33-8uryunVRtrplzK6nZyipFHe2EG6hUQgkrO9sNPZdWgm16JngjmkE7DUKIFeeddrxlVDSn1fkh7y7Fb6WmbLYeHYyjDRAnNK0STSO0LuDZP-AmTimU2gxnHRedZrxArw7QjR3B-DDEnKzbZzSXTGshdNOpQi3vocroYetdDDD4Ev9LcP6HYA22vBHGcdp_Et6b2aWImGAwu-S3Nt0ZRs3eHgY3ptjDzPYogpdzV9OqfOkRn_1QgNczYNHZcUg2OI9HrpVcdj87vzhwWI7CDaTj8_z36hcHRdgbDn6n_HX-A6413F0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219249812</pqid></control><display><type>article</type><title>Maturation of the expression of adrenomedullin, endothelin-1 and nitric oxide synthases in adipose tissues from childhood to adulthood</title><source>Nature_系列刊</source><creator>Knerr, I ; Schirl, C ; Horbach, T ; Stuppy, A ; Carbon, R ; Rascher, W ; Dötsch, J</creator><creatorcontrib>Knerr, I ; Schirl, C ; Horbach, T ; Stuppy, A ; Carbon, R ; Rascher, W ; Dötsch, J</creatorcontrib><description>OBJECTIVE:
To investigate if the vasoactive systems adrenomedullin (ADM) and endothelin-1 (ET-1) are expressed in human adipose tissues in children and in adults and to determine the distribution pattern of nitric oxide synthases (NOS).
DESIGN AND SUBJECTS:
Subcutaneous, mesenterial and omental adipose tissue specimens taken from 15 children (age 0.5–16 y, median 6 y) and 13 adults (age 43–79 y, median 60 y) were analyzed. The body mass indices (BMI) were within the normal range. All patients were normotensive, and were free of infectious disease, and metabolic or endocrine disorders. The specimens were taken during elective laparotomies after informed consent was obtained.
MEASUREMENTS:
ADM, ET-1, the endothelial (eNOS) and inducible (iNOS) NOS as well as two housekeeping genes were measured using quantitative real-time PCR.
RESULTS:
ADM gene expression was found at all locations, and was significantly higher in adults than in children (
P
<0.01 for subcutaneous and omental adipose tissue). ET-1 mRNA was distributed in a similar way, showing significantly higher levels in the subcutaneous and mesenterial adipose tissue sections of adults than of children. For eNOS, the adult patients exhibited a higher expression in subcutaneous and mesenterial specimens than the children (
P
<0.01 and
P
<0.05). The iNOS mRNA was increased in subcutaneous, mesenterial and omental adipose tissues in the adult cohort compared to the children's levels (
P
<0.05 to
P
<0.01).
CONCLUSION:
Human adipose tissue expresses many vasoactive substances including ADM and ET-1. In adults, the amounts of ET-1 and ADM as well as eNOS and iNOS mRNA are higher, possibly due to a physiological upregulation with increasing age. Although there are differences depending on the locations of the tissues, the expression patterns of the antagonists ADM and ET-1 are quite similar, indicative of a well-balanced pattern of local gene expression in normotensive individuals with normal body weight.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0802885</identifier><identifier>PMID: 15672108</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adipocytes ; Adipose tissue ; Adipose Tissue - metabolism ; Adolescent ; Adrenomedullin ; Adult ; Adults ; Aged ; Aging - metabolism ; Biological and medical sciences ; Body fat ; Body Mass Index ; Body weight ; Child ; Child, Preschool ; Endocrine disorders ; Endothelin-1 - genetics ; Endothelin-1 - metabolism ; Epidemiology ; Female ; Gene expression ; Gene Expression Regulation, Developmental ; Health Promotion and Disease Prevention ; Humans ; Infant ; Infectious diseases ; Insulin ; Internal Medicine ; Laparotomy ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Mesentery - metabolism ; Metabolic Diseases ; Metabolism ; Middle Aged ; Nitric oxide ; Nitric Oxide Synthase - genetics ; Nitric Oxide Synthase - metabolism ; Nitric Oxide Synthase Type II ; Nitric Oxide Synthase Type III ; Obesity ; Omentum - metabolism ; Peptides ; Peptides - genetics ; Peptides - metabolism ; Physiology ; Public Health ; RNA, Messenger - genetics ; Subcutaneous Tissue - metabolism</subject><ispartof>International Journal of Obesity, 2005-03, Vol.29 (3), p.275-280</ispartof><rights>Springer Nature Limited 2005</rights><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-1ccb581ba770c094cf057474a59a9fd25a5ea3d142343f8c8e444b2298c261043</citedby><cites>FETCH-LOGICAL-c576t-1ccb581ba770c094cf057474a59a9fd25a5ea3d142343f8c8e444b2298c261043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16525912$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15672108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knerr, I</creatorcontrib><creatorcontrib>Schirl, C</creatorcontrib><creatorcontrib>Horbach, T</creatorcontrib><creatorcontrib>Stuppy, A</creatorcontrib><creatorcontrib>Carbon, R</creatorcontrib><creatorcontrib>Rascher, W</creatorcontrib><creatorcontrib>Dötsch, J</creatorcontrib><title>Maturation of the expression of adrenomedullin, endothelin-1 and nitric oxide synthases in adipose tissues from childhood to adulthood</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>OBJECTIVE:
To investigate if the vasoactive systems adrenomedullin (ADM) and endothelin-1 (ET-1) are expressed in human adipose tissues in children and in adults and to determine the distribution pattern of nitric oxide synthases (NOS).
DESIGN AND SUBJECTS:
Subcutaneous, mesenterial and omental adipose tissue specimens taken from 15 children (age 0.5–16 y, median 6 y) and 13 adults (age 43–79 y, median 60 y) were analyzed. The body mass indices (BMI) were within the normal range. All patients were normotensive, and were free of infectious disease, and metabolic or endocrine disorders. The specimens were taken during elective laparotomies after informed consent was obtained.
MEASUREMENTS:
ADM, ET-1, the endothelial (eNOS) and inducible (iNOS) NOS as well as two housekeeping genes were measured using quantitative real-time PCR.
RESULTS:
ADM gene expression was found at all locations, and was significantly higher in adults than in children (
P
<0.01 for subcutaneous and omental adipose tissue). ET-1 mRNA was distributed in a similar way, showing significantly higher levels in the subcutaneous and mesenterial adipose tissue sections of adults than of children. For eNOS, the adult patients exhibited a higher expression in subcutaneous and mesenterial specimens than the children (
P
<0.01 and
P
<0.05). The iNOS mRNA was increased in subcutaneous, mesenterial and omental adipose tissues in the adult cohort compared to the children's levels (
P
<0.05 to
P
<0.01).
CONCLUSION:
Human adipose tissue expresses many vasoactive substances including ADM and ET-1. In adults, the amounts of ET-1 and ADM as well as eNOS and iNOS mRNA are higher, possibly due to a physiological upregulation with increasing age. Although there are differences depending on the locations of the tissues, the expression patterns of the antagonists ADM and ET-1 are quite similar, indicative of a well-balanced pattern of local gene expression in normotensive individuals with normal body weight.</description><subject>Adipocytes</subject><subject>Adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Adolescent</subject><subject>Adrenomedullin</subject><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Aging - metabolism</subject><subject>Biological and medical sciences</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Endocrine disorders</subject><subject>Endothelin-1 - genetics</subject><subject>Endothelin-1 - metabolism</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Insulin</subject><subject>Internal Medicine</subject><subject>Laparotomy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mesentery - metabolism</subject><subject>Metabolic Diseases</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Nitric oxide</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Nitric Oxide Synthase Type II</subject><subject>Nitric Oxide Synthase Type III</subject><subject>Obesity</subject><subject>Omentum - metabolism</subject><subject>Peptides</subject><subject>Peptides - genetics</subject><subject>Peptides - metabolism</subject><subject>Physiology</subject><subject>Public Health</subject><subject>RNA, Messenger - genetics</subject><subject>Subcutaneous Tissue - metabolism</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp1kk2PFCEQhjtG446rV28assY92bNAQ0MfNxu_kjVe9EwYunqHSQ-MFJ3s_gF_t4zTOmrWcACK5y2q4K2q54wuGW30BW6WfhOXVFOutXxQLZhQbS1Fpx5WC9pQVVPZypPqCeKGUiol5Y-rEyZbxRnVi-r7J5unZLOPgcSB5DUQuN0lQJwjtk8Q4hb6aRx9eEMg9LFQZV0zYkNPgs_JOxJvfQ8E70JeWwQkPhSp30UEkj3iVEJDilvi1n7s1zH2JMdCTGPeb55WjwY7Ijyb59Pq67u3X64-1Nef33-8uryunVRtrplzK6nZyipFHe2EG6hUQgkrO9sNPZdWgm16JngjmkE7DUKIFeeddrxlVDSn1fkh7y7Fb6WmbLYeHYyjDRAnNK0STSO0LuDZP-AmTimU2gxnHRedZrxArw7QjR3B-DDEnKzbZzSXTGshdNOpQi3vocroYetdDDD4Ev9LcP6HYA22vBHGcdp_Et6b2aWImGAwu-S3Nt0ZRs3eHgY3ptjDzPYogpdzV9OqfOkRn_1QgNczYNHZcUg2OI9HrpVcdj87vzhwWI7CDaTj8_z36hcHRdgbDn6n_HX-A6413F0</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Knerr, I</creator><creator>Schirl, C</creator><creator>Horbach, T</creator><creator>Stuppy, A</creator><creator>Carbon, R</creator><creator>Rascher, W</creator><creator>Dötsch, J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>Maturation of the expression of adrenomedullin, endothelin-1 and nitric oxide synthases in adipose tissues from childhood to adulthood</title><author>Knerr, I ; Schirl, C ; Horbach, T ; Stuppy, A ; Carbon, R ; Rascher, W ; Dötsch, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c576t-1ccb581ba770c094cf057474a59a9fd25a5ea3d142343f8c8e444b2298c261043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adipocytes</topic><topic>Adipose tissue</topic><topic>Adipose Tissue - metabolism</topic><topic>Adolescent</topic><topic>Adrenomedullin</topic><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Aging - metabolism</topic><topic>Biological and medical sciences</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>Body weight</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Endocrine disorders</topic><topic>Endothelin-1 - genetics</topic><topic>Endothelin-1 - metabolism</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Health Promotion and Disease Prevention</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Insulin</topic><topic>Internal Medicine</topic><topic>Laparotomy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mesentery - metabolism</topic><topic>Metabolic Diseases</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Nitric oxide</topic><topic>Nitric Oxide Synthase - genetics</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Nitric Oxide Synthase Type II</topic><topic>Nitric Oxide Synthase Type III</topic><topic>Obesity</topic><topic>Omentum - metabolism</topic><topic>Peptides</topic><topic>Peptides - genetics</topic><topic>Peptides - metabolism</topic><topic>Physiology</topic><topic>Public Health</topic><topic>RNA, Messenger - genetics</topic><topic>Subcutaneous Tissue - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knerr, I</creatorcontrib><creatorcontrib>Schirl, C</creatorcontrib><creatorcontrib>Horbach, T</creatorcontrib><creatorcontrib>Stuppy, A</creatorcontrib><creatorcontrib>Carbon, R</creatorcontrib><creatorcontrib>Rascher, W</creatorcontrib><creatorcontrib>Dötsch, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Knerr, I</au><au>Schirl, C</au><au>Horbach, T</au><au>Stuppy, A</au><au>Carbon, R</au><au>Rascher, W</au><au>Dötsch, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maturation of the expression of adrenomedullin, endothelin-1 and nitric oxide synthases in adipose tissues from childhood to adulthood</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>29</volume><issue>3</issue><spage>275</spage><epage>280</epage><pages>275-280</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>OBJECTIVE:
To investigate if the vasoactive systems adrenomedullin (ADM) and endothelin-1 (ET-1) are expressed in human adipose tissues in children and in adults and to determine the distribution pattern of nitric oxide synthases (NOS).
DESIGN AND SUBJECTS:
Subcutaneous, mesenterial and omental adipose tissue specimens taken from 15 children (age 0.5–16 y, median 6 y) and 13 adults (age 43–79 y, median 60 y) were analyzed. The body mass indices (BMI) were within the normal range. All patients were normotensive, and were free of infectious disease, and metabolic or endocrine disorders. The specimens were taken during elective laparotomies after informed consent was obtained.
MEASUREMENTS:
ADM, ET-1, the endothelial (eNOS) and inducible (iNOS) NOS as well as two housekeeping genes were measured using quantitative real-time PCR.
RESULTS:
ADM gene expression was found at all locations, and was significantly higher in adults than in children (
P
<0.01 for subcutaneous and omental adipose tissue). ET-1 mRNA was distributed in a similar way, showing significantly higher levels in the subcutaneous and mesenterial adipose tissue sections of adults than of children. For eNOS, the adult patients exhibited a higher expression in subcutaneous and mesenterial specimens than the children (
P
<0.01 and
P
<0.05). The iNOS mRNA was increased in subcutaneous, mesenterial and omental adipose tissues in the adult cohort compared to the children's levels (
P
<0.05 to
P
<0.01).
CONCLUSION:
Human adipose tissue expresses many vasoactive substances including ADM and ET-1. In adults, the amounts of ET-1 and ADM as well as eNOS and iNOS mRNA are higher, possibly due to a physiological upregulation with increasing age. Although there are differences depending on the locations of the tissues, the expression patterns of the antagonists ADM and ET-1 are quite similar, indicative of a well-balanced pattern of local gene expression in normotensive individuals with normal body weight.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15672108</pmid><doi>10.1038/sj.ijo.0802885</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2005-03, Vol.29 (3), p.275-280 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67433488 |
| source | Nature_系列刊 |
| subjects | Adipocytes Adipose tissue Adipose Tissue - metabolism Adolescent Adrenomedullin Adult Adults Aged Aging - metabolism Biological and medical sciences Body fat Body Mass Index Body weight Child Child, Preschool Endocrine disorders Endothelin-1 - genetics Endothelin-1 - metabolism Epidemiology Female Gene expression Gene Expression Regulation, Developmental Health Promotion and Disease Prevention Humans Infant Infectious diseases Insulin Internal Medicine Laparotomy Male Medical sciences Medicine Medicine & Public Health Mesentery - metabolism Metabolic Diseases Metabolism Middle Aged Nitric oxide Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Obesity Omentum - metabolism Peptides Peptides - genetics Peptides - metabolism Physiology Public Health RNA, Messenger - genetics Subcutaneous Tissue - metabolism |
| title | Maturation of the expression of adrenomedullin, endothelin-1 and nitric oxide synthases in adipose tissues from childhood to adulthood |
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