Male patients with paranoid schizophrenia have greater ACTH and cortisol secretion in response to metoclopramide-induced AVP release

Dynamic testing of the hypothalamic-pituitary–adrenal axis in schizophrenia has yielded conflicting results, which may be related to patient selection and previous exposure to psychotropic medication. The objective of this study was to determine the pattern of corticotropin (ACTH) and cortisol relea...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2005-06, Vol.30 (5), p.431-437
Main Authors: Walsh, Patricia, Spelman, Leona, Sharifi, Neda, Thakore, Jogin H.
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Adrenocorticotrpin
Adult
Adult and adolescent clinical studies
Arginine Vasopressin - metabolism
Behavioral psychophysiology
Biological and medical sciences
Cortisol
Dopamine Antagonists - pharmacology
Fundamental and applied biological sciences. Psychology
Hormones and behavior
Humans
Hydrocortisone - blood
Hypothalamic–pituitary–adrenal axis
Male
Medical sciences
Metoclopramide
Metoclopramide - pharmacology
Neurotransmission and behavior
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia, Paranoid - blood
Schizophrenia, Paranoid - psychology
Vasopressin
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Summary:Dynamic testing of the hypothalamic-pituitary–adrenal axis in schizophrenia has yielded conflicting results, which may be related to patient selection and previous exposure to psychotropic medication. The objective of this study was to determine the pattern of corticotropin (ACTH) and cortisol release in response to metoclopramide (a dopamine antagonist), which appears to be unique in its ability to release vasopressin (AVP), in drug naïve patients with schizophrenia experiencing their first episode of psychosis. In this study, we examined AVP, ACTH and cortisol release in response to metoclopramide in 10 drug-naive, first-episode male patients with a DSM IV diagnosis of paranoid schizophrenia and compared them to healthy control subjects matched for age, sex and smoking status. Patients, as compared to controls had higher levels of baseline plasma cortisol (375.5±47.4/l vs. 273.8±42.2 nmol/l, respectively; t=2.48, df=9, p< 0.02) and plasma ACTH (14.9±0.85 vs. 11.3±0.57 pg/ml, respectively; t=4.29, df=9, p
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2004.11.003