Symmetry of callosal information transfer in schizophrenia: a preliminary study

While there is much evidence to suggest left hemisphere dysfunction and interhemispheric transfer deficits in schizophrenia, the right hemisphere is rarely implicated. This study uses 128-channel EEG to assess whether asymmetry of interhemispheric transfer found in normal individuals is present in t...

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Bibliographic Details
Published in:Schizophrenia research 2005-05, Vol.74 (2), p.171-178
Main Authors: Barnett, Kylie J., Corballis, Michael C., Kirk, Ian J.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Corpus callosum
Corpus Callosum - physiopathology
EEG
Electroencephalography
Functional Laterality - physiology
Humans
Interhemispheric transfer time (IHTT)
Male
Medical sciences
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Reaction Time - physiology
Right hemisphere
Schizophrenia
Schizophrenia - complications
Schizophrenia - physiopathology
Visual Fields - physiology
Visual Perception - physiology
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Summary:While there is much evidence to suggest left hemisphere dysfunction and interhemispheric transfer deficits in schizophrenia, the right hemisphere is rarely implicated. This study uses 128-channel EEG to assess whether asymmetry of interhemispheric transfer found in normal individuals is present in those with schizophrenia, and whether this might point to a right-hemisphere dysfunction. Simple reaction time (RT) was recorded to stimuli presented to the left visual field (LVF), right visual field (RVF) or bilaterally (BVF) in 13 males with schizophrenia and 13 controls. 128-Channel EEG was simultaneously recorded. Interhemispheric transfer time (IHTT) in each direction was calculated by comparing the latencies of N160 EP components in the hemispheres contralateral and ipsilateral to stimulation. While controls showed faster information transfer from the right-to-left hemisphere, this asymmetry was not present in the schizophrenia group who also exhibited a concomitant decrease in the amplitude of the N160 in the right hemisphere. Results are interpreted with reference to a loss of rapidly conducting myelinated axons in the right hemisphere in schizophrenia.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2004.08.007