A peptide-catalyzed asymmetric Stetter reaction

Thiazolylalanine, in appropriately functionalized form, has been found to function as an enantioselective catalyst for an intramolecular Stetter reaction. Incorporation of the residue in a number of environments has resulted in a family of catalysts that promote the cyclization of a test substrate w...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2005-01 (2), p.195-197
Main Authors: Mennen, Steven M, Blank, Jarred T, Tran-Dubé, Michelle B, Imbriglio, Jason E, Miller, Scott J
Format: Article
Language:English
Subjects:
Alanine - analogs & derivatives
Benzoin - chemistry
Catalysis
Cyclization
Molecular Structure
Peptides - chemistry
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Summary:Thiazolylalanine, in appropriately functionalized form, has been found to function as an enantioselective catalyst for an intramolecular Stetter reaction. Incorporation of the residue in a number of environments has resulted in a family of catalysts that promote the cyclization of a test substrate with up to 81% enantiomeric excess.
ISSN:1359-7345
1364-548X
DOI:10.1039/b414574g