Reduced plasma total homocysteine concentrations in Type 1 diabetes mellitus is determined by increased renal clearance

• Published in: Diabetic medicine 2005-03, Vol.22 (3), p.301-305
• Main Authors: Veldman, B. A. J., Vervoort, G., Blom, H., Smits, P.
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Case-Control Studies; Chi-Square Distribution; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Glomerular Filtration Rate; homocysteine; Homocysteine - blood; Humans; Insulin; Kidney - blood supply; Kidney - metabolism; Male; Medical sciences; p-Aminohippuric Acid; Regional Blood Flow; Regression Analysis; renal clearance; Type 1 diabetes mellitus
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1111/j.1464-5491.2005.01415.x

Introduction  Elevated plasma levels of total homocysteine are related to the development of vascular complications. Patients with diabetes mellitus are particularly at risk for the development of these complications. Several factors determine plasma total homocysteine including renal function. Aims  As early Type 1 diabetes is characterized by a relative glomerular hyperfiltration, increased renal clearance could contribute to decreased levels of homocysteine as observed in Type 1 diabetes mellitus. Therefore we investigated the relationship between plasma total homocysteine and the glomerular filtration rate (GFR). Methods  In 92 Type 1 diabetes patients and 44 control subjects, we measured GFR and effective renal plasma flow (ERPF) by means of continuous infusion of inulin and p‐aminohippurate. Fasting plasma total homocysteine was measured using high performance liquid chromatography. Results  GFR (121 ± 21 resp. 104 ± 14 ml/min; P