In vivo demonstration of the anatomic differences between classic and occult choroidal neovascularization using optical coherence tomography

To determine architectural differences between classic and occult choroidal neovascularization (CNV) in vivo. Prospective observational case series. Twenty-two patients with acute CNV underwent fluorescein angiography and optical coherence tomography (OCT), which were analyzed by separate blinded ob...

Full description

Saved in:
Bibliographic Details
Published in:American journal of ophthalmology 2005-02, Vol.139 (2), p.344-346
Main Authors: Hughes, Edward H., Khan, Jaheed, Patel, Nishal, Kashani, Shahram, Chong, N. Victor
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Choroid - pathology
Choroidal Neovascularization - diagnosis
Diagnostic Techniques, Ophthalmological
Extracellular Space
Female
Fluorescein Angiography
Humans
Macular degeneration
Male
Medical sciences
Middle Aged
Occult sciences
Ophthalmology
Pigment Epithelium of Eye - pathology
Pilot Projects
Retina
Retinopathies
Tomography, Optical Coherence - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To determine architectural differences between classic and occult choroidal neovascularization (CNV) in vivo. Prospective observational case series. Twenty-two patients with acute CNV underwent fluorescein angiography and optical coherence tomography (OCT), which were analyzed by separate blinded observers. In 87.5% of angiographically labeled “classic” CNV a discreet subretinal lesion corresponding to the neovascular complex could be seen above and separate to the retinal pigment epithelium on OCT. This was found in only 13.3% of “occult” CNV. With the latest commercially available OCT equipment it is now possible to confirm in vivo the previously proposed anatomic differences between fluorescein angiographically labeled classic and occult CNV. Classic CNV appear to grow predominantly in the subretinal space, whereas the majority of occult lesions do not. Optical coherence tomography features of CNV may correlate with response to photodynamic therapy or angiostatic treatments, as well as predicting the success of surgical removal.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2004.07.058