Gender differences in growth hormone response to exercise before and after rhGH administration and the effect of rhGH on the hormone profile of fit normal adults

Summary Objectives  Exercise is a potent physiological stimulus of GH secretion. We hypothesized that exogenous recombinant human growth hormone (rhGH) administration through an increase in GH and IGF‐I levels would blunt the GH response to exercise. The aim of the study was to examine and compare t...

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Published in:Clinical endocrinology (Oxford) 2005-03, Vol.62 (3), p.315-322
Main Authors: Giannoulis, M. G., Boroujerdi, M. A., Powrie, J., Dall, R., Napoli, R., Ehrnborg, C., Pentecost, C., Cittadini, A., Jørgensen, J. O. L., Sonksen, P. H.
Format: Article
Language:English
Subjects:
Adult
Anthropometry
Biological and medical sciences
Dose-Response Relationship, Drug
Double-Blind Method
Endocrinopathies
Exercise - physiology
Female
Fundamental and applied biological sciences. Psychology
Gonadal Hormones - blood
Human Growth Hormone - blood
Human Growth Hormone - pharmacology
Human Growth Hormone - secretion
Humans
Insulin-Like Growth Factor I - metabolism
Male
Medical sciences
Pituitary Hormones - blood
Recombinant Proteins - pharmacology
Sex Characteristics
Vertebrates: endocrinology
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Summary:Summary Objectives  Exercise is a potent physiological stimulus of GH secretion. We hypothesized that exogenous recombinant human growth hormone (rhGH) administration through an increase in GH and IGF‐I levels would blunt the GH response to exercise. The aim of the study was to examine and compare the impact of rhGH on the exercise‐induced GH response in healthy normal men and women. Design and Measurements  Sixty‐nine subjects (36 men, 33 women) were randomized to receive low‐dose rhGH (0·1 U/kg/day), high dose rhGH (0·2 U/kg/day), or placebo. Subjects were matched for age (24 ± 3·1), and body mass index (BMI). rhGH was given as a single subcutaneous (s.c.) injection for the first 28 days. All subjects exercised to exhaustion (maximal oxygen consumption – VO2max) before rhGH treatment (Test 1), and on day 28 (Test 2). GH was measured before exercise (time 0), immediately after exercise (time 0′) and at 15, 30, 60, 90 and 120 min postexercise. Baseline IGF‐I levels were measured before exercise on days 0 and 28. Results  Baseline IGF‐I levels showed no gender differences (42·3 women vs. 38·8 nmol/l men) but basal GH values were higher in women (9·9 vs. 1·8 mU/l, P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2005.02216.x