The dawn of cognitive genetics? Crucial developmental caveats

Attempts to bridge genetics and cognition are rapidly coming to the forefront of cognitive neuroscience. It is therefore crucial to evaluate the current state of knowledge about disorders of known genetic origin as a way of assessing whether, and if so how, links between genotype and cognitive pheno...

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Bibliographic Details
Published in:Trends in cognitive sciences 2005-03, Vol.9 (3), p.126-135
Main Authors: Scerif, Gaia, Karmiloff-Smith, Annette
Format: Article
Language:English
Subjects:
Brain - growth & development
Child
Child, Preschool
Cognitive Science - trends
Cooperative Behavior
Forecasting
Genetics, Behavioral - trends
Genotype
Humans
Infant
Interprofessional Relations
Neural Networks (Computer)
Neurosciences - trends
Phenotype
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Summary:Attempts to bridge genetics and cognition are rapidly coming to the forefront of cognitive neuroscience. It is therefore crucial to evaluate the current state of knowledge about disorders of known genetic origin as a way of assessing whether, and if so how, links between genotype and cognitive phenotype can be drawn, however indirect these links might be. We review recent empirical findings from research on genetic disorders at three levels of description – cognitive, neural systems, and cellular – that caution against simple genotype–phenotype mappings at all levels. Most importantly, interdisciplinary efforts to integrate human genetics and cognition will need to operationalize the mechanisms driving both typical and atypical developmental processes over time.
ISSN:1364-6613
1879-307X
DOI:10.1016/j.tics.2005.01.008