Biocompatibility of titanium implants modified by microarc oxidation and hydroxyapatite coating

A thin hydroxyapatite (HA) layer was coated on a microarc oxidized titanium (MAO‐Ti) substrate by means of the sol–gel method. The microarc oxidation (anodizing) enhanced the biocompatibility of the Ti, and the bioactivity was improved further by the sol–gel HA coating on the anodized Ti. The HA sol...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2005-04, Vol.73A (1), p.48-54
Main Authors: Li, Long-Hao, Kim, Hae-Won, Lee, Su-Hee, Kong, Young-Min, Kim, Hyoun-Ee
Format: Article
Language:English
Subjects:
Absorbable Implants
Alkaline Phosphatase - metabolism
Cell Line, Tumor
Cell Proliferation - drug effects
Durapatite - chemistry
Humans
hydroxyapatite sol-gel coating
in vitro cell responses
Materials Testing
microarc oxidation (MAO)
Microscopy, Electron, Scanning
Oxidation-Reduction
titanium
Titanium - chemistry
Titanium - pharmacology
titanium, in vitro cell responses
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Summary:A thin hydroxyapatite (HA) layer was coated on a microarc oxidized titanium (MAO‐Ti) substrate by means of the sol–gel method. The microarc oxidation (anodizing) enhanced the biocompatibility of the Ti, and the bioactivity was improved further by the sol–gel HA coating on the anodized Ti. The HA sol was aged fully to obtain a stable and phase‐pure HA, and the sol concentration was varied to alter the coating thickness. Through the sol–gel HA coating, the Ca and P concentrations in the coating layer increased significantly. However, the porous morphology and roughness of the MAO‐Ti was altered very little by the sol–gel treatment. The proliferation and alkaline phosphatase (ALP) activity of the osteoblast‐like cells on the MAO/HA sol–gel‐treated Ti were significantly higher than those on the MAO‐Ti without the HA sol–gel treatment. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res 73A: 48–54, 2005
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.30244