Total mandibular reconstruction for massive osteolysis of the mandible (Gorham–Stout syndrome)

• Published in: British journal of oral & maxillofacial surgery 2005-04, Vol.43 (2), p.166-168
• Main Authors: Paley, M.D., Lloyd, C.J., Penfold, C.N.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Bone Transplantation - methods; Dentistry; Diseases of the osteoarticular system; Female; Fibula - transplantation; Gorham–Stout syndrome; Humans; Joint Prosthesis; Mandible; Mandible - surgery; Mandibular Diseases - surgery; Massive osteolysis; Medical sciences; Middle Aged; Miscellaneous. Osteoarticular involvement in other diseases; Oral Surgical Procedures; Osteolysis, Essential - surgery; Otorhinolaryngology. Stomatology; Reconstruction; Recurrence; Reoperation; Syndrome; Temporomandibular Joint - surgery
• ISSN: 0266-4356; 1532-1940
• DOI: 10.1016/j.bjoms.2004.09.008

Massive osteolysis (Gorham–Stout syndrome) is a rare condition of unknown aetiology that is thought to result from a localised endothelial proliferation of lymphatic vessels resulting in destruction and absorption of bone. The diagnosis of Gorham–Stout syndrome can be made only after first excluding osteolysis from infection, inflammation, endocrine disease, and cancer. The syndrome is rarely seen in the facial skeleton and has a variable prognosis. Many treatments have been advocated but only surgery and radiotherapy have had some success. We present a case of massive osteolysis of the entire mandible, which was reconstructed with a free vascularised fibular graft and bilateral prosthetic replacements of the temporomandibular (TMJ) joints. Four years later the fibular graft had been absorbed requiring further reconstruction with another fibula graft.