The roles of vitamin A for cytoplasmic maturation of bovine oocytes

Vitamin A is one of the micronutrients which have been implicated in cattle reproduction. In cattle, ingested vitamin A, mainly as beta-carotene (BC) from forages and retinol ester from formula feed, is metabolized and transported to the oocytes and cumulus-granulosa cells in ovarian follicles throu...

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Bibliographic Details
Published in:Journal of Reproduction and Development 2005, Vol.51(1), pp.23-35
Main Authors: Ikeda, S.(Kyoto Univ. (Japan)), Kitagawa, M, Imai, H, Yamada, M
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
beta Carotene - metabolism
CAROTENOIDE
CAROTENOIDES
CAROTENOIDS
Cattle
CITOPLASMA
COWS
Culture Techniques
CYTOPLASM
Cytoplasm - metabolism
CYTOPLASME
Cytoplasmic maturation
Embryonic Development
EXPRESION GENICA
EXPRESSION DES GENES
Female
Fertilization in Vitro - methods
GENE EXPRESSION
Granulosa Cells - cytology
Insemination, Artificial - methods
MADURACION
MATURATION
Models, Chemical
Oocyte
Oocytes - metabolism
Oogenesis
OVA
Ovarian Follicle - metabolism
Ovary - metabolism
OVULE
OVULO
Ovum - metabolism
Prostaglandin-Endoperoxide Synthases - metabolism
RETINOL
Tretinoin - metabolism
VACA
VACHE
Vitamin A
Vitamin A - chemistry
Vitamin A - metabolism
Vitamin A - physiology
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Summary:Vitamin A is one of the micronutrients which have been implicated in cattle reproduction. In cattle, ingested vitamin A, mainly as beta-carotene (BC) from forages and retinol ester from formula feed, is metabolized and transported to the oocytes and cumulus-granulosa cells in ovarian follicles through binding to various interacting molecules. The active form of vitamin A, retinoic acid (RA), functions as a regulator of gene expression in these targets. Early research showed the positive effects of vitamin A supplementation on bovine fertility in artificial insemination, and several studies on effects of vitamin A metabolites used in other artificial reproductive techniques (ART), including superovulation, ovum pick up, and in vitro maturation culture have provided evidence for the specific roles of vitamin A in oocyte cytoplasmic maturation (acquisition of developmental competence of oocytes during their meiotic maturation period for the embryonic development after fertilization). BC may enhance cytoplasmic maturation by its antioxidant properties which cannot be replaced by RA. Furthermore, RA may promote cytoplasmic maturation of bovine oocytes via its modulatory effects on the gene expression of gonadotrophin receptors, midkine, cyclooxygenase-2, and nitric oxide synthase in cumulus-granulosa cells.
ISSN:0916-8818
1348-4400
DOI:10.1262/jrd.51.23