Effect of oxcarbazepine on sleep architecture

Abstract The most common side effects following administration of antiepileptic drugs involve alterations in sleep architecture and varying degrees of daytime sleepiness. Oxcarbazepine is a drug that is approved as monotherapy for the treatment of partial seizures and generalized tonic–clonic seizur...

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Bibliographic Details
Published in:Epilepsy & behavior 2009-07, Vol.15 (3), p.287-290
Main Authors: Ayala-Guerrero, Fructuoso, Mexicano, Graciela, González, Valentín, Hernandez, Mario
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Anticonvulsants - therapeutic use
Behavior, Animal - drug effects
Brain - physiology
Carbamazepine - analogs & derivatives
Carbamazepine - pharmacology
Electroencephalography
Electromyography - methods
Hypnotic effects
Male
Neck Muscles - physiology
Neurology
Oxcarbazepine
Rapid eye movement sleep
Rats
Rats, Wistar
Sleep - drug effects
Sleep, REM - drug effects
Slow wave sleep
Time Factors
Wakefulness - drug effects
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Summary:Abstract The most common side effects following administration of antiepileptic drugs involve alterations in sleep architecture and varying degrees of daytime sleepiness. Oxcarbazepine is a drug that is approved as monotherapy for the treatment of partial seizures and generalized tonic–clonic seizures. However, there is no information about its effects on sleep pattern organization; therefore, the objective of this work was to analyze such effects. Animals (Wistar rats) exhibited three different behavioral and electrophysiological states of vigilance: wakefulness, slow wave sleep (SWS), and rapid eye movement (REM) sleep. Oral treatment with oxcarbazepine (100 mg/kg) produced an increment in total sleep time throughout the recording period. This increment involved both SWS and REM sleep. Mean duration of the REM sleep phase was not affected. In contrast, the frequency of this sleep phase increased significantly across the 10-hour period. REM sleep latency shortened significantly. Results obtained in this work indicate that oxcarbazepine’s acute effects point to hypnotic properties.
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2009.04.013